Institution
Cancer Research UK Manchester Institute
Recent research
- Health & MedicineOpen access
Abstract Background Salvage surgery for local regrowth following watch-and-wait (W&W) after total neoadjuvant therapy (TNT) is perceived to be technically more difficult than immediate surgery after treatment. However, surgical difficulty lacks standardised definition and reporti...
- BiologyOpen access
Abstract Mitosis is triggered when the rising activity of CDK1-Cyclin B, amplified by the CDK1/Cdc25/Wee1 feedback loop, overcomes inhibitory signalling from Wee1 and counteracting phosphatases. CDK-opposing phosphatases PP1, PP2A-B55 and PP2A-B56 are regulators of mitosis. A scr...
- BiologyOpen access
Paediatric therapeutic development workshop on osteosarcoma
The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...
- Health & Medicine
Frontline blinatumomab combined with chemotherapy has resulted in improved outcomes in both pediatric and adult patients with acute lymphoblastic leukemia and is considered the new cornerstone of acute lymphoblastic leukemia treatment. The role of asparaginase in this new landsca...
- BiologyOpen access
The influence of hypoxia on cancer lipid metabolism: a scoping review
Abstract Background Hypoxia, a hallmark of solid tumours, profoundly alters cellular metabolism to enable survival in the harsh tumour microenvironment. Whilst effects on carbohydrate and protein metabolism are well characterised, the hypoxic regulation of lipid metabolism remain...