Cancer Institute (WIA)

Double primary malignancies in head-and-neck cancer: Clinicodemographic profile, treatment patterns, and outcomes – A retrospective analysis from a tertiary cancer center

Abstract: BACKGROUND: Double primary malignancies (DPMs) in the head-and-neck region represent a distinct and challenging clinical entity. This study describes the clinicodemographic profile, treatment patterns, and outcomes of patients presenting with DPMs at a tertiary cancer c...

Polycyclic aromatic hydrocarbons, gut microbiome composition, impulsivity, and attention covary in a human cohort

ABSTRACT Polycyclic aromatic hydrocarbons (PAHs) are pervasive environmental pollutants linked to adverse neurobehavioral outcomes, yet the biological pathways coupling exposure to behavior are poorly defined. The gut microbiome is both sensitive to PAH exposure and a modulator o...

Prekallikrein: the catalytic crossroads of inflammation and thrombosis

PURPOSE OF REVIEW: The contact activation pathway, historically considered dispensable for hemostasis, has re-emerged as a critical mediator of thromboinflammation. Plasma prekallikrein, through its activation to kallikrein, links coagulation, inflammation, and vascular biology....

Current Trends in Therapeutic Outcomes Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A Systematic Review and Meta-Analysis

Study Design Systematic Review. Objectives The objective of this study was to answer two questions: (1) Did the overall survival (OS) of patients with spinal metastatic renal cell carcinoma (mRCC) improve in publications from 2017 and afterwards compared to 2016 and before? (2) D...

Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy dura...

Recognizing and Addressing Fertility Issues among Childhood Cancer Patients and Survivors in India – A Multi Stakeholder Position Statement and Call to Action

Abstract Survival rates in childhood and adolescent cancers have improved substantially over the past decades, leading to a growing population of long-term survivors. In India, an estimated 76,000 children and adolescents are diagnosed with cancer annually, and approximately one-...

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways

Sporadic pancreatic neuroendocrine tumors (pNETs) with wild type MEN1 represent a major yet largely ignored subset whose biology and metastatic potential remain poorly understood. Because metastasis can occur despite low histologic grade and modest mutational burden, we hypothesi...

Stereoselectivity inLiquid Aerosols through Acid-MediatedEpoxide Ring-Opening Reactions

Abstract Stereoisomers in aqueous atmospheric aerosols are assumed to be present in equal concentrations, as aerosols are most commonly mixtures of simple inorganic salts with a range of organic species that lack obvious pathways to induce stereoselectivity. Further, since submic...