Cancer Hospital of Shantou University Medical College

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

ABSTRACT Tumor extracellular matrix (ECM) remodeling and cell‐intrinsic mechanical properties critically limit nanoparticle (NP) delivery, yet how these multiscale biophysical cues are coordinately regulated remains unclear. Here, we identify focal adhesion kinase (FAK/ PTK2 ) as...

Linking centromere stretch to SAC signaling in mammalian oocytes with insights from modified kinetochore model

Abstract The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalia...

Identification of ADH4 from a ferroptosis-oxidative stress prognostic model in hepatocellular carcinoma

Abstract Background Ferroptosis is a recently identified form of regulated cell death that is closely associated with oxidative stress and redox homeostasis. Although ferroptosis-related prognostic models have been developed for hepatocellular carcinoma (HCC), the prognostic valu...

Predicting dengue incidence in China using SARIMA and hybrid neural network models: insights for public health planning

Abstract Dengue fever remains a persistent public health challenge in tropical and subtropical regions of China, disproportionately affecting economically disadvantaged and resource-limited areas. Outbreaks of dengue can strain healthcare systems and hinder socio-economic develop...

48-hour BPRI trajectories and 28-day mortality in vasoactive-supported hypertensive heart disease with heart failure

Hypertensive heart disease (HHD) complicated by heart failure is associated with high mortality in intensive care units. The Blood Pressure Response Index (BPRI), the ratio of mean arterial pressure to vasoactive-inotropic score, integrates hemodynamic targets and treatment inten...

A clinico-radiomic nomogram for preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in early-stage cervical cancer

To develop and validate an integrated clinico-radiomic nomogram for the preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in patients with FIGO stage IB–IIA cervical cancer. A total of 200 patients who underwent radical hysterectomy were...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Comparative efficacy and toxicity of two versus three induction chemotherapy cycles in locally advanced nasopharyngeal carcinoma: a propensity score matching analysis

Abstract Background For patients with locally advanced nasopharyngeal carcinoma (LA-NPC), the optimal number of cycles of induction chemotherapy (IC) remains uncertain. This study aimed to assess the efficiency and toxicity of different cycles of IC in LA-NPC patients. Methods Th...