Cancer Hospital of Chinese Academy of Medical Sciences

Extracellular Vesicles: Emerging Players in Tumor Progression, Diagnosis, and Therapeutic Applications

Abstract Extracellular vesicles (EVs) are emerging as critical players in oncology and also exert vital regulatory effects on exercise-induced muscle injury repair, offering novel insights into tumor biology. Tumor-derived EVs facilitate intercellular communication by carrying bi...

Triple Genetic Alterations (EGFR Mutation, ALK Fusion, and MET Polysomy) in Gynecological Metastasis of Lung Adenocarcinoma Patient with Acquired Resistance to Furmonertinib: A Case Report

For advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations, targeted therapy is the standard first-line treatment, but acquired resistance and disease progression are inevitable. Identification of resistance mechanisms is crucial for gu...

Demoted CD4+ T-cell activity resulted from CTNNB1 mutations resists lenvatinib plus anti-PD1 in HCC

Abstract Hepatocellular carcinoma (HCC) patients frequently fail to respond to combined anti-PD1 immunotherapy, though pre-existing neoantigen-specific CD8⁺ T cells within tumor microenvironment are reinvigorated upon PD1 blockaded. Tumor-intrinsic mechanisms driving the therapeu...

TOP2A Overexpression as a Prognostic Biomarker in High-Grade Meningioma: An Integrated Single-Cell and Bulk Transcriptomic Study

While prior single-cell studies have identified proliferative neoplastic subpopulations, the prognostic and therapeutic implications of TOP2A focal copy-number status have not been defined. This study aimed to delineate the cellular architecture of high-grade meningioma and to ev...

Bioorthogonal Assembly of Cell-Nanoparticle Hybrids Enables Synergistic Cancer Therapy

Abstract Integrating nanoparticles (NPs) with living cells into a unified therapeutic system remains a major methodological challenge. Here, we describe a robust and modular bioorthogonal strategy for constructing cell-nanoparticle hybrids (CNHs) via sequential thiazolidine forma...

Clinical Utility of Drug-Eluting Beads Bronchial Arterial Chemoembolization in Advanced Refractory Non-Small Cell Lung Cancer

Objective: This study mainly focused on evaluating the efficacy and safety of drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) in treating advanced refractory non-small cell lung cancer (NSCLC) patients, with an exploratory investigation of whether combining DEB...

Performance of a five-gene plasma cfDNA methylation assay for colorectal cancer detection: a single-center real-world analysis

Blood-based circulating cell-free DNA (cfDNA) methylation assays have been proposed as minimally invasive tools for colorectal cancer (CRC) detection, but their performance under routine clinical conditions may differ from model-development studies. We evaluated the real-world di...

MXene/Bi12O17Cl2/Bi2S3 Ternary Schottky-Type II Heterojunction: Photothermal Boosted Interfacial Charge Transfer for Ultrasensitive Photoelectrochemical Sensing of Tetracycline

Constructing multicomponent heterojunctions to extend carrier lifetime is a common strategy to improve the sensitivity of photoelectrochemical (PEC) sensing. However, sluggish interfacial charge-transfer kinetics still limit the utilization efficiency of photogenerated carriers....

Methyl indole-3-acetate contributes to strain-specific anti-inflammatory effects of Lactiplantibacillus plantarum

Lactiplantibacillus plantarum is a widely recognized probiotic with anti-inflammatory potential, yet its efficacy varies among strains and the underlying determinants remain poorly defined. Here, we identify methyl indole-3-acetate (MIA), a previously uncharacterized microbial me...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

P1.154. Delayed Unexplained Hemorrhage After Esophagectomy: Insights From a Nationwide Multicenter Questionnaire-Based Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Delayed unexplained postoperative hemorrhage after esophagectomy is a rare complication. Due to its low incidence, existing reports are limited, and high-qualit...