Cancer Genetics (United States)

Socioeconomic status and longitudinal neurocognitive outcomes following childhood brain tumour diagnosis: a Swedish national population-based cohort study

Abstract Background Lower socioeconomic status (SES) is linked to poorer neurocognitive development in the general population, but these effects in paediatric brain tumour survivors are underexplored. We examined the relationship between parental SES, clinical factors, and neuroc...

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Abstract Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning...

Why Women Don't Return: Nurse Perspectives on Follow‐Up Care After Abnormal Cervical Cancer Screening Results in Mississippi's Public Health System

ABSTRACT Objective To explore public health nurses’ perspectives on reasons women in Mississippi may fail to receive follow‐up care after abnormal cervical cancer (CC) screenings. Background Mississippi’s high cervical cancer mortality rate poses a significant public health chall...

Psychological distress in adult patients with colorectal cancer: roles of biological age and neighborhood deprivation

Abstract Introduction Depression and anxiety are common in adults with colorectal cancer (CRC), especially during chemotherapy, yet underlying biosocial mechanisms remain unclear. We examined whether biological age predicts these symptoms and whether neighborhood deprivation ampl...

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a...

Unacknowledged Burdens and Clinical Assets of BIPOC Genetic Counseling Students: Qualitative Evidence to Inform Supervision

As the genetic counseling profession works to diversify its predominantly white workforce, understanding the experiences of Black, Indigenous, and People of Color (BIPOC) students is central to equity efforts. While BIPOC students bring invaluable cultural and linguistic diversit...

Integrative multiomic analysis identifies transcription factors and target proteins in renal cell carcinoma

Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...