Cancer Center Amsterdam

Necroptosis as a key player in cervical cancer progression and management: a systematic review and transcriptomic cross-study consensus analysis

Immunotherapy has improved outcomes for a subset of patients with locally advanced cervical cancer. However, many tumors remain immunologically "cold" and fail to respond. Strategies that enhance tumor immunogenicity are therefore of increasing interest. Necroptosis, a regulated...

MAIA frailty subgroup analysis: long-term follow-up with daratumumab plus lenalidomide/dexamethasone in transplant-ineligible newly diagnosed myeloma

Abstract In MAIA (Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma), daratumumab plus lenalidomide/dexamethasone (D-Rd) improved progression-free survival (PFS) and overall survival (OS) versus Rd in tran...

Good Quality of Life 3 Decades After Rotationplasty

Background: Long-term quality of life (QoL) after rotationplasty is important because prolonged patient survival has become more common. This study assessed QoL decades after rotationplasty. Methods: This cross-sectional study included surviving patients who had been treated for...

Metabolic and DNA-based assays provide equally reliable measures of cell viability across experimental conditions

Accurately and reliably assessing cell viability is a fundamental necessity in biomedical research. However, many cytotoxic compounds used in cancer research have both on- and off-target effects on cellular metabolism, which may confound metabolism-based cell viability assessment...

The classification for Adverse events in GastRointEstinal Endoscopy (AGREE): three-year evaluation and additional recommendations

Background In 2021, a novel classification for gastrointestinal endoscopy-related adverse events (AEs) was introduced: the AGREE classification. This classification was developed to minimize subjectivity in AE assessment and facilitate more robust comparisons of endoscopic and su...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Feasibility of radiomics and deep learning methods for prognosis of non–small cell lung cancer using 18F-FDG PET/CT

Accurate prognostication for non-small cell lung cancer (NSCLC) is challenging due to tumor heterogeneity and the limitations of conventional PET biomarkers. This technical feasibility study compared the difference in prognostic performance of radiomics and deep learning (CNN) me...

Reducing sialylation in melanoma increases classical pathway-mediated complement activation

Summary Based on the success in pre-clinical models, methods that reduce sialylation in tumors have progressed to clinical trials, as this improves anti-tumor cellular responses. Immune responses against cancer can also be mediated by soluble, non-cellular mechanisms, such as the...

In-human assessment of target engagement and blockade of radiolabeled BI 765063, an anti-SIRPα antibody

The signal regulatory protein alpha (SIRPα) receptor on myeloid cells binds cluster of differentiation (CD) antigen CD47 on tumor cells, resulting in a “don’t eat me” signal that inhibits phagocytosis. BI 765063, an anti-SIRPα antibody, may restore anti-tumor immunity by blocking...