Canada's Michael Smith Genome Sciences Centre

Extracellular vesicles from chemoresistant breast cancer cells reprogram macrophages toward an M2-like phenotype in an ABCC1-dependent manner

Triple-negative breast cancer is characterized by high rates of chemoresistance and poor clinical outcomes. Although ATP-binding cassette (ABC) transporters are well-established mediators of drug efflux, their role in tumor–immune communication remains poorly defined. Here, we in...

Federated EGA in the European and Global Human Data Ecosystem

This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...

Revealing the genetic mechanisms underpinning the parasite-induced water-seeking behaviour of insects through RNA-seq

Abstract Water-seeking behaviour in arthropods infected by mermithid nematodes or nematomorphs is a classic example of host manipulation, yet its molecular basis remains poorly understood. We investigated mechanisms underlying this aberrant behaviour in European earwigs (Forficul...

ntSynt-viz: Visualizing synteny patterns across multiple genomes

Abstract With the explosion of chromosome-scale genome assemblies being generated in recent years, there is vast potential for comparative genomics analyses through detecting multi-genome synteny. While existing tools can detect synteny blocks between multiple genomes, their text...