California NanoSystems Institute

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

Pair distribution analysis of short- and medium-range order of metallic glasses: Direct imaging and diffraction-based approaches

Abstract Pair distribution function (PDF) analysis provides a quantitative framework for resolving short- and medium-range order in glasses. This article summarizes recent advances that extend PDF methods from bulk x-ray and neutron-diffraction methods to local electron microscop...

Pixel super-resolved fluorescence lifetime imaging using deep neural networks

Abstract Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical adoption remains limited by long pixe...

Encapsulation of AAVs into Protein Vault Nanoparticles as a Novel Solution to Gene Therapy’s Neutralizing Antibody Problem

Abstract Although adeno-associated virus (AAV) has enjoyed enormous success as a delivery modality for gene therapy, it suffers from high prevalence of preexisting neutralizing antibodies in human populations, limiting who can receive potentially life-saving treatments. As a nove...