California Institute for Regenerative Medicine

Pre-Governance in Production: A Single-Operator Case Study of Constraint-First Governance at the Deployment Decision Surface

v1.1 (2026-08-22) withdraws this study's expiry findings. The status recorded as EXPIRED in the governance trace denotes a consumed approval, not an unadjudicated timeout: it is written when an escalation is approved, to spend a one-time approval. The timeout path writes a differ...

From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation

The persistent shortage of human organs for transplantation has intensified efforts to develop alternative sources, specifically xenotransplantation and exogenesis. Xenotransplantation uses genetically engineered pigs to provide organs, tissues, and cells for clinical use. Signif...