California Animal Hospital

Enhanced molecular diagnosis of Onchocerca lupi using droplet digital PCR in clinically suspected companion animals

Abstract Background Onchocerca lupi , a zoonotic filarial nematode documented in southwestern North America and the Old World, is associated with ocular onchocerciosis in dogs and cats. Clinical signs range from ocular discharge and conjunctivitis to chronic nodular lesions invol...

Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming

Osteoarthritis (OA) lacks approved disease-modifying therapies. Here, by integrating quantitative proteomics with reanalysis of public single-cell RNA sequencing data from human articular cartilage, we identify thymidine kinase 1 (TK1) as a pathogenic regulator linking inflammato...