Calgary Laboratory Services

Taming the Fire: Lung Sparing MDA-5 DM and MAS Overlap Successfully Treated with Methylprednisolone, Rituximab, IVIG, Anakinra, and Tofacitinib

Background Anti-melanoma differentiation-associated protein 5 (MDA5) Dermatomyositis (DM) can be refractory to multiple lines of immunosuppression.[1] Here, we present a case of refractory MDA-5 DM with Macrophage Activation Syndrome (MAS) overlap requiring numerous immunosuppres...