Butler Hospital

The Effect of Stimulant Medications on Symptom and Treatment Outcomes in Adults With Comorbid Attention-Deficit/Hyperactivity and Substance Use Disorder: A Systematic Review and Meta-Analysis

Objective Symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) are increasingly recognized among adults and frequently co-occur with substance use disorders (SUD). Changing guidelines and complexity of treatment merit a review of approaches for managing this diagnostic ove...

Linguistic features from paragraph recall are markers of cognitive impairment

Abstract Objective Cognitive impairment is associated with language changes that may be elicited from verbal responses during neuropsychological assessments that are not captured in traditional scoring. The current study investigated the utility of a linguistic analysis of paragr...

Before lowering blood pressure to prevent ARIA, we need evidence of net benefit

Amyloid-related imaging abnormalities (ARIA) occur in 20-40% of patients treated with the amyloid-targeting drugs lecanemab and donanemab. While most cases of ARIA are asymptomatic, serious and fatal cases occur. Therefore, ARIA prevention remains vital as these drugs are increas...

Before lowering blood pressure to prevent ARIA, we need evidence of net benefit

Amyloid-related imaging abnormalities (ARIA) occur in 20-40% of patients treated with the amyloid-targeting drugs lecanemab and donanemab. While most cases of ARIA are asymptomatic, serious and fatal cases occur. Therefore, ARIA prevention remains vital as these drugs are increas...

Artificial Intelligence–Based Detection of ARIA on MRI During Alzheimer Disease Therapy: Expert Opinion on Responsible Clinical Integration

Amyloid-targeted monoclonal antibody therapies have introduced a new era in the treatment of early Alzheimer disease. However, their use has increased the importance of detecting and monitoring amyloid-related imaging abnormalities (ARIA) on MRI, as such findings may influence tr...

Distinct Patterns of Intentional and Unintentional Overdose Among Psychiatric Patients With Bipolar and Substance Use Disorders.

BACKGROUND: Co-occurrence of Bipolar Disorder (BD) and Substance Use Disorder (SUD) increases the risk of negative mental health outcomes, including both intentional (i.e., suicide self-poisoning) and unintentional overdose (i.e., accidental). While it is clear that both forms of...