Burdenko Neurosurgery Institute

Microsurgical resection of brain metastases: rationale, appropriateness and local control

OBJECTIVE: To summarize data on indications for microsurgical resection of brain metastases, effect of resection technique on local control and leptomeningeal dissemination, as well as the role of stereotactic radiosurgery in improving local control. MATERIAL AND METHODS: A descr...

Clinical presentation of brain abscesses: from classic triad to silent forms

Despite relatively small incidence, brain abscesses are life-threatening with high risk of death and persistent neurological deficits. A key factor limiting early diagnosis is polymorphic and nonspecific clinical presentation. OBJECTIVE: To analyze the structure and incidence of...

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

Abstract Medulloblastoma is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evalu...

Management of metastatic spinal disease in low- and middle-income countries: an international survey of practices and challenges in Latin America

Spinal metastases impose urgent diagnostic and therapeutic demands; however, evidence from low- and middle-income countries (LMICs) in Latin America is sparse. We aimed to characterize real-world practices, access gaps, and priorities to in-form context-adapted guidelines. We con...