Bunkyo University

How Organizational Design Facilitates Team Outcomes: The Mediating Role of Knowledge-Creation Processes in Healthcare Organizations

Knowledge-intensive organizations rely on multidisciplinary collaboration, yet the organizational structures that convert specialized knowledge into collective capabilities remain insufficiently understood. This cross-sectional study examined whether knowledge-creation processes...

pdb2reaction : End-to-End Reaction-Path Elucidation from PDB Structures Using Machine-Learning Interatomic Potentials

Abstract Elucidating enzymatic reaction mechanisms requires a sequence of computational tasks comprising active-site extraction, minimum-energy-path search, transition-state (TS) refinement, intrinsic reaction coordinate (IRC) validation, and quasi-rigid-rotor harmonic-oscillator...

Multiscale Analysis on Seismic Response of Underground RC Structure with Uniformly Corroded Sidewall: Effect of Strengthening Using Various Methods

This study numerically investigates the seismic response of corroded underground reinforced concrete (RC) culverts strengthened using various methods. A multiscale model for corrosion and seismic analysis, accounting for strengthening effects, was first validated through quasi-st...

A High-Density Supercritical Fluid of H2

Abstract This study aimed to elucidate the structural evolution of supercritical fluid hydrogen (SCF H2) under high pressure. X-ray diffraction was performed on SCF H2 using synchrotron radiation at room temperature. The structure factor S(Q) was observed in a low-Q region at eac...

A Well-Being-Centric Walkable Tourism Platform Using AI Agent

We propose a Well-Being-Centric Walkable Tourism Platform Using AI Agent that fuses heterogeneous urban data—an OSM pedestrian graph, a city-scale microclimate field, and a walkability layer for Sofia, Bulgaria—with an AI agent that converts freetext user requests into a constrai...

Targeting the Zinc Metalloproteinase Superfamily in the CNS: Medicinal Chemistry Strategies To Optimize Selectivity, Pharmacokinetics, and Blood–Brain Barrier Permeability

Abstract The zinc metalloproteinase superfamily [matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAMs with thrombospondin motifs (ADAMTSs)] represents a high-value yet elusive therapeutic target for peripheral disorders and central nervous sys...

PREOPERATIVE PAIN SENSITIVITY HAS A GREATER IMPACT ON CLINICAL OUTCOMES THAN CORONAL ALIGNMENT STRATEGY IN ROBOTIC-ASSISTED TOTAL KNEE ARTHROPLASTY: IMPLICATIONS FOR TRIAL DESIGN

Introduction Both pre-operative pain sensitivity and coronal alignment philosophy may influence patient-reported outcomes (PROMs) after total knee arthroplasty (TKA). This study investigated whether pain sensitivity predicts function in robotic-assisted TKAs 19andomized to functi...

uniSynK: a ratio-optimized bicistronic chemically induced dimerization tool for robust induction of dendritic spine enlargement

Synaptic plasticity is widely implicated in learning and brain-state regulation. Although correlations between synaptic modifications and diverse brain functions have been extensively reported, establishing causality requires tools that can directly and selectively perturb synaps...

Impact of Inhibitor Size and Flexibility on the Binding Pathways to c-Src Kinase

Abstract The conformational plasticity of protein kinases poses a challenge for inhibitor design, motivating the use of molecular dynamics (MD) simulations to study their dynamic binding processes. While conformational changes are increasingly discussed, the impact of drug compou...

A Capsid Tyrosine Residue Governs the Proteolytic Inactivation of Echovirus 11 in Lakewater

Abstract Enteroviruses are environmentally transmissible human pathogens whose stability in natural waters varies widely, yet the molecular determinants underlying this variability remain largely unknown. Echovirus 11 (E11), a reemerging cause of severe neonatal infections, is ef...

Staggered Quadruple-Rutile Oxides as Low-Strain and High-Power Anodes for Lithium-Ion Batteries

Abstract Tunnel-structured oxides provide attractive hosts for lithium-ion storage. However, their application is frequently limited by structural instability or sluggish ion transport at high lithium contents. Here, we demonstrate that the staggered quadruple-rutile framework re...

“Smelltronics”—From Gas to Smell Sensing

This review discusses recent trends in smell and odor-sensing studies, including materials, devices, and interfaces. Since the invention of chemical sensors, particularly over the past few decades, gas sensor materials and devices for small molecules have been extensively investi...

Controlling Valence Band for Cu2Sn0.38Ge0.62S3 Particles via Li Substitution at Cu Sites

Abstract Cu2(Sn,Ge)S3 (CTGS) is a promising near-infrared-responsive photocathode material whose conduction band minimum can be tuned by varying the Sn/Ge ratio, whereas direct control of the valence band maximum (VBM) remains challenging because of the large Cu 3d contribution t...

A Programmable Nanovesicle Platform for MegapascalPressure Sensing

Abstract Hydrostatic pressure (HP) is a subtle yet pervasive force that shapes chemistry and biology from the ocean floor to living cells─yet real-time HP sensing at the microscale remains elusive. Here, we report pyrene-modified polyionic complex vesicles (Pyr-PICsomes) as a cla...

A ComplexSpin-Transition Thermal Hysteresis Unlockedby Two Competing Symmetry-Breakings

Abstract The spin-crossover material [Fe(NH2trz)3](NO3)2 belongs to the class of 1D triazole-based polymeric SCO complexes. It exhibits a thermal phase transition, with a 28 K wide thermal hysteresis, characterized by phase transition temperatures T↑ = 346 K upon warming and T↓ =...

Coordination-Driven Transport in Chloroaluminate Electrolytes

Abstract Transport in electrolytes reflects both the stability of coordination complexes and their dynamic reorganization through chemical bond association and dissociation. Establishing an atomistic description of how the dynamic coordination governs equilibrium speciation and t...

Pressure-SelectiveMagnetic Switching via SpatiallySeparated Soft Interlayer and Rigid Charge-Transfer Intralayer

Abstract We report a pressure-responsive molecule-based magnet featuring a layered cyanido-bridged Co–W assembly, [{CoII(4-phenoxypyridine)4}3{WV(CN)8}2], exhibiting a distinct pressure-selective magnetic behavior. The compound forms two-dimensional charge-transfer layers with la...

Marine-DegradableParamylon Ethers and Ether–EsterDerivatives with Tunable Thermoplasticity and Controlled DissolutionBehavior

Abstract Paramylon, a β-1,3-glucan from Euglena gracilis, is a promising renewable feedstock for biodegradable plastics, but its dense hydrogen-bonding network limits thermoplastic processing. Methyl paramylon (PaMe), ethyl paramylon (PaEt), and paramylon methyl acetate ether–est...

Synthesis ofUnsymmetrically 1,3,5-TrisubstitutedArenes via Site-Selective Sequential Silylation and Borylation

Abstract A catalytic, site-selective silylation and borylation sequence allows the synthesis of unsymmetrically 1,3,5-trisubstituted arenes. A spirobipyridine ligand bearing a “steric roof”, in combination with iridium creates a catalyst that recognizes the shape of a monosubstit...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...