Brain Mapping Foundation

Increases in Regional Brain Volume and Thickness Following ECT and Relationships With Changes in Depressive Symptoms and Peripheral Inflammation

OBJECTIVES: Treatment-resistant depression (TRD) is highly prevalent and debilitating. Electroconvulsive therapy (ECT) is an efficacious intervention for TRD. This study sought to clarify ECT's mechanisms by examining relationships between ECT-induced changes in regional brain vo...

Aβ-42 Side Chain Deamidation at Q15 or N27 Modulates Protein Aggregation and Alters Microglial Cytokines and CD68

The progressive aggregation of amyloid beta (Aβ) monomers into oligomers is a critical factor in Alzheimer's disease (AD) pathogenesis. Although mutated forms of Aβ have been shown to display altered aggregation dynamics, the specific effects of deamidated Aβ on microglial functi...

Neural mechanisms of sensory over-responsivity in youth with early caregiver-related adversity

Abstract Sensory over-responsivity (SOR) is an impairing sensory processing challenge prevalent across a range of clinical and neurodevelopmental populations, as well as those with experiences of early caregiver-related adversity. Despite its prevalence and impairing nature, litt...

Early sleep and sensory over-responsivity relate to insular functional connectivity with sensorimotor cortices and cerebellum in infants at varying likelihood for autism

Abstract Sleep problems and sensory over-responsivity (SOR) are common, co-occurring, and early emerging features of Autism Spectrum Disorder (ASD). Yet, the early neural mechanisms underlying these symptoms remain unclear. Here, we used resting-state fMRI data from the Infant Br...