Blizard Institute

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Multi-omics analyses reveal key immunological and metabolic correlates of mortality in HIV-associated Pneumocystis pneumonia

Pneumocystis jirovecii pneumonia (PCP) remains a major cause of life-threatening respiratory failure in people with advanced HIV, yet the biological factors associated with mortality are incompletely understood. We performed integrated transcriptomic, proteomic, and metabolomic p...

Process mapping: finding new routes to guideline adherence

Invited commentary of Shaw, L., Wilson, C., Haskell, L. et al. Process mapping to design theory-informed strategies reducing inappropriate HFNC use in emergency bronchiolitis care. Pediatr Res (2026). https://doi.org/10.1038/s41390-026-05304-w

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity

Abstract Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity. However, its potency is often limited by innate immune responses, particularly t...