B.J. Medical College

A systematic review of system dynamics and agent-based models: Mathematical modelling for health systems research

Background: Mathematical modelling has emerged as a powerful approach for analysing complex healthcare systems, which exhibit nonlinear interactions, feedback loops, and adaptive behaviours. Among available techniques, System Dynamics Modelling (SDM) and Agent-Based Modelling (AB...

Efficacy of early blood purification on serum inflammatory mediators in severe acute pancreatitis: a systematic review and meta-analysis

Severe acute pancreatitis (SAP) is the most critical form of acute pancreatitis (AP), characterized by a dysregulated systemic inflammatory response that drives early organ failure and mortality. Current management remains mainly supportive. Early blood purification (EBP) has bee...

Real-world outcomes and immune-related adverse events with PD-1/ PD-L1 inhibitors in metastatic renal cell carcinoma: A prospective observational study

Objectives: Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have changed the management of metastatic renal cell carcinoma (mRCC). Most pivotal trials come from high-income settings and include highly selected patients. Prospective real-world data from low- and...

Clinicopathological characteristics, diagnostic challenges, and systemic implications of metastatic tumors to the eyelid: a systematic review

Abstract Background Metastatic tumors to the eyelid are rare but clinically significant, often indicating advanced systemic malignancy or presenting as the first sign of an occult primary. Histopathology is the diagnostic cornerstone, yet the spectrum of clinicopathological patte...