Birjand University of Medical Sciences

Cell-free supernatant of Limosilactobacillus reuteri enhances 5-fluorouracil-induced apoptosis in SW-480 colorectal cancer cells: an in vitro study

5-fluorouracil (5-Fu) is a main treatment for colorectal cancer (CRC) but shows limited efficacy and serious side effects, creating a need for novel adjunct therapies. Recent evidence suggests Limosilactobacillus reuteri derivatives may have anticancer properties. Accordingly, th...

HER2-Low Breast Cancer: A Review of Epidemiology, Diagnostic Challenges, Targeted Therapies, and Clinical Outcomes

Background: Breast cancer is the most common malignancy among women. The HER2-low subgroup represents one of its prevalent subtypes; however, due to its unique characteristics, it presents challenges in diagnosis and treatment, complicating clinical management. This narrative rev...

Exploring medical interns’ perceptions and satisfaction with task-based microlearning in an otolaryngology rotation: a mixed-methods study

Abstract Background The integration of traditional and modern educational approaches in contemporary curricula, particularly in medical education, is becoming increasingly necessary. Medical schools and healthcare institutions are seeking to enhance the effectiveness and efficien...

Renal and hepatic injury markers trajectories and respiratory symptoms in iron ore processing plant workers

Abstract Mining is a high-risk occupation, with mineral dust exposure leading to various occupational diseases. This study aimed to assess respiratory symptoms and longitudinal changes in renal and hepatic injury markers among workers occupationally exposed to iron dust and cryst...

Downregulation of miR-223 in a cyclophosphamide-induced mouse model of premature ovarian failure: histological and hormonal correlations

Premature ovarian failure (POF) is characterized by early ovarian dysfunction leading to infertility and hormonal imbalance. microrna-223 (MiR − 223) is a key microRNA that regulates multiple cellular processes, including inflammation, apoptosis, and follicular development. Emerg...

Patient attitudes of smartphone use by medical staff in teaching hospital emergency departments

Purpose This study investigate patient attitudes towards the use of smartphones by medical staff in teaching hospital emergency departments. Design/methodology/approach This cross-sectional, descriptive-analytical study was conducted in 2023 in the emergency departments of Ferdow...

Psychometric properties of the Persian version of Pressure Ulcer Management Self-Efficacy Scale for nurses

Background: Pressure ulcers remain a major clinical challenge, and nurses’ self-efficacy is essential for their prevention and management. The Pressure Ulcer Management Self-Efficacy Scale (PUM-SES) for nurses was developed to assess this competency. Aim: This study aimed to tran...

Phytochemical-mediated design of magnetic MgFe2S4/CoBiO2I heterojunction for enhanced photocatalytic degradation of ciprofloxacin

This study addresses the environmental threat of ciprofloxacin (CIP) by presenting a nanocomposite synthesized via a plant-extract-mediated route, which eliminates the need for harsh chemical reducing agents. This approach minimizes the use of hazardous chemicals while maintainin...

Investigating the Effect of Reflection Through Visual Self-Evaluation

This study investigated the effect of visual self-evaluation and faculty feedback on students' clinical skills acquisition. It was a quasi-experimental design involving a pre-test and post-test for a single group. The participants were 32 Iranian nursing students. The skills eval...

Synergistic effects of Tschimgine combined with 5-Fluorouracil against HT-29 human colorectal cancer cells

Colorectal cancer (CRC) represents a leading cause of cancer morbidity and mortality globally. Tschimgine (Tsc), a naturally occurring terpenoid from Ferula ovina , has exhibited potent anticancer activity in preclinical models. However, its ability to enhance the sensitivity of...