BioTechMed-Graz

Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations

Reductive amination catalysed by imine reductases and reductive aminases has emerged as a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, we combine large-scale, iterative...

Deciphering the evolutionary origin of the enantioselectivity of short-chain dehydrogenases from plants toward 1-borneol

Abstract Enzyme engineering has produced numerous methods to optimize enzymes for biotechnological processes; however, less is known about how natural evolution creates new functionalities. We investigate the evolutionary emergence of enantioselectivity in plant borneol dehydroge...

Stereodivergent Sequential One‐Pot/Two‐Step Photo‐Biocatalytic Cascade for the Synthesis of Enantioenriched 1‐Arylalkan‐1‐ols From α‐Methylstyrenes

Artificial photo‐biocatalytic cascades offer an attractive platform for the sustainable and selective synthesis of high‐value chiral molecules. Here, we report a sequential one‐pot/two‐step cascade that integrates metal‐free photoredox catalysis with alcohol dehydrogenase (ADH)‐m...