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Recent research
- Biology
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...
- Health & MedicineOpen access
Cytomegalovirus Latency Fuels Inflammation Following Myocardial Infarction
BACKGROUND: Epidemiological studies have consistently associated cytomegalovirus (CMV) seropositivity with adverse cardiovascular outcomes. However, the mechanisms by which cytomegalovirus infection impacts pathophysiology in the heart remain poorly understood. In this study, we...
- Health & MedicineOpen access
ABSTRACT The difructose dianhydride I synthase/hydrolase catalyzes the reversible transformation of inulobiose into difructose dianhydride I, a component of caramel. The proposed reaction mechanism of such a transformation consists of a glycosylation step followed by a cyclizatio...
- BiologyOpen access
Qualitative changes in binocular rivalry experience with age
Abstract Binocular rivalry is a visual phenomenon that occurs when two dissimilar stimuli are presented to each eye. The perception alternates between dominance periods when one of the stimuli is perceived with brief transition periods in between, providing a unique window into t...
- BiologyOpen access
Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various senso...
- Materials & EnergyOpen access
Reductive amination catalysed by imine reductases and reductive aminases has emerged as a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, we combine large-scale, iterative...
- BiologyOpen access
Abstract Enzyme engineering has produced numerous methods to optimize enzymes for biotechnological processes; however, less is known about how natural evolution creates new functionalities. We investigate the evolutionary emergence of enantioselectivity in plant borneol dehydroge...
- Materials & Energy
Artificial photo‐biocatalytic cascades offer an attractive platform for the sustainable and selective synthesis of high‐value chiral molecules. Here, we report a sequential one‐pot/two‐step cascade that integrates metal‐free photoredox catalysis with alcohol dehydrogenase (ADH)‐m...