BioSyntha Technology (United Kingdom)

Discovery of Stereoselective UrCYP71AU Oxidases Catalyzing the Final Biosynthetic Step of Rhynchophylline and Mechanistic Insights into 7R and 7S Spiroindole Skeleton Formation

Abstract Rhynchophylline (RHY) is a spiroindole alkaloid that acts on the cardiovascular and central nervous systems. Based on the distribution patterns of 7R and 7S spiroindole alkaloids in U. rhynchophylla, we hypothesize the existence of hirsutine oxidase responsible for 7R an...