BioSurfaces (United States)

Generative Chemistry Platform for Small Molecules Targeting RNA: A Case Study for Chemical Optimization

Abstract We introduce the Serna Bio GenAI platform, a generative chemistry and multiparametric optimization platform for the design of RNA-targeting small molecules. Targeting RNA with small molecules has proven historically challenging but offers notable potential upsides, inclu...

Experimental evidence and consequences of biomolecular corona formation on inhaled mRNA lipid nanoparticles

Abstract Inhalable messenger RNA (mRNA) therapeutics are moving pulmonary drug delivery from local deposition of small molecules toward transient, programmable expression of antigens, secreted proteins, antibodies, gene-editing enzymes and replacement proteins directly within the...

Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy

Gut microbial metabolites play crucial roles in regulating systemic immunity, but their mechanisms and limited drug-like properties remain unresolved. Here we report an oral nano-formulation that leverages gut microbial metabolites to modulate T cell metabolism and amplify antitu...

A rapid approach to detect methicillin-resistant and susceptible Staphylococcus aureus directly from clinical specimens

ABSTRACT Screening of methicillin-resistant/susceptible Staphylococcus aureus (MRSA/MSSA) is important for healthcare facilities to prevent hospital-acquired infections. The two common MRSA screening approaches are culture-based testing with selective and/or differential properti...