Bioengineering Center

Intercellular Transfer of CD155 Mediated by Melanoma Extracellular Vesicles Downregulates DNAM-1 Expression on NK Cells

Melanoma is a highly immunogenic cancer, and immunotherapy is the first-line treatment for patients with advanced disease. However, CD155 overexpression in melanoma has been associated with resistance to immunotherapy. Whether CD155 can be transferred from tumour cells via extrac...

Thermochemical Valorization of Silkworm Feeding Waste: Chemical Characterization and Biological Activities of the Pyrolysis-Derived Liquid Fraction

Silkworm-rearing residues are an underused biomass resource that can be converted into value-added products. In this study, a condensable liquid product (SWP-Liq) was produced from these residues by pyrolysis at 325 ± 5 °C and evaluated for its chemical composition and in vitro b...

Cyclic Ion Mobility Separations of Free Oxylipins

Abstract Oxylipins are oxygenated lipid metabolites derived from polyunsaturated fatty acids (PUFAs). They play interconnected roles in physiological processes such as inflammation and vascular function, and their dysregulation has been linked to diseases, including cardiovascula...

Neurological symptoms during incretin receptor agonist therapy: current evidence for metabolic and fluid-electrolyte mechanisms and testable hypotheses

This focused review examines the current evidence linking neurological symptoms during tirzepatide treatment to metabolic and fluid-electrolyte disturbances. Evidence from regulatory documents, randomised trials, human physiology, pharmacovigilance analyses, and case reports is s...

Neurological symptoms during incretin receptor agonist therapy: current evidence for metabolic and fluid-electrolyte mechanisms and testable hypotheses

This focused review examines the current evidence linking neurological symptoms during tirzepatide treatment to metabolic and fluid-electrolyte disturbances. Evidence from regulatory documents, randomised trials, human physiology, pharmacovigilance analyses, and case reports is s...

Temporal Ordering of Astrocytic and Lipid-Handling Biomarkers Relative to Phosphorylated Tau in Genetically At-Risk Alzheimer's Disease: A Systematic Review and Structured Synthesis

This record contains the preprint and supporting materials for a prospectively registered systematic review evaluating whether astrocytic or lipid-handling biomarkers precede phosphorylated tau (p-tau) in populations at genetic risk for Alzheimer’s disease. The review was registe...

Connectivity maintenance cost in the brain CMC II: energetic margins, local reserves, and failure thresholds

This theoretical study develops the Connectivity Maintenance Cost (CMC) framework by modelling how biological and neural networks lose functional integration when the resources available for connectivity maintenance fall below critical thresholds. Rather than treating energetic e...

Connectivity maintenance cost in the brain CMC II: energetic margins, local reserves, and failure thresholds

This theoretical study develops the Connectivity Maintenance Cost (CMC) framework by modelling how biological and neural networks lose functional integration when the resources available for connectivity maintenance fall below critical thresholds. Rather than treating energetic e...

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

Xyloglucan (an α‐1,6‐xylosyl–substituted β‐1,4‐glucan) is a major hemicellulose of the primary cell wall of many plants and an important growth substrate for biomass‐degrading bacteria in diverse ecological niches, including the gut microbiome and hot springs. In Gram‐positive ba...