Bioef - Fundación Vasca de Innovación e Investigación Sanitarias

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Porphyrin-Cross-Linked Unimolecular Polyglycerol Nanogels: Confinement-Controlled Metalation and Selective Cu2+ Detection

Abstract Unimolecular nanogels (NGs) based on (hyper)branched cyclic polyglycerols ((h)bcPGs) of two molecular weights (Mn = 8 and 60 kDa) were prepared through intramolecular cross-linking with the tetraboronic acid–functionalized porphyrin, 5,10,15,20-(tetra-4-dihydroxyborylphe...

Noncarbohydrate Inhibitors of Sialic Acid-Binding Immunomodulatory-Type Lectin-7 (Siglec-7) Discovered from Genetically Encoded Bicyclic Peptide Libraries

ABSTRACT Glycan-binding proteins (GBP) are among the most difficult to drug targets. This deficiency delays clinical progress for therapeutically important GBPs. We employed bicyclic genetically encoded libraries (BiGELs), produced by chemical modification of phage-displayed libr...

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME

Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) are leading causes of visual impairment and require long-term intravitreal anti-vascular endothelial growth factor (VEGF) therapy. However, treatment burden and suboptimal real-world outcomes rem...

Cell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

Extracellular vesicles (EVs) mediate intercellular communication in the central nervous system (CNS) and are emerging as biomarkers of brain health and disease. However, the molecular composition of cell type-specific brain EVs, particularly astrocyte-derived EVs (ADEVs), remains...