Biodesigns (United States)

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse over nearly two weeks of development. From one embryo, we reconstruct a time-calibr...

Translation Landscape of Corneal Endothelial Tissue Engineering: A Scoping Review

Background Corneal endothelial dysfunction is a leading cause of global blindness. The main treatment is full keratoplasty, for which access is limited due to the worldwide shortage of tissue donors. Corneal tissue engineering has shown significant progress, yet there are still c...