Biocon (Switzerland)

Intercellular Transfer of CD155 Mediated by Melanoma Extracellular Vesicles Downregulates DNAM-1 Expression on NK Cells

Melanoma is a highly immunogenic cancer, and immunotherapy is the first-line treatment for patients with advanced disease. However, CD155 overexpression in melanoma has been associated with resistance to immunotherapy. Whether CD155 can be transferred from tumour cells via extrac...

Draft genome sequence of Bacillus paranthracis S23, isolated from saline soil of Lake Bogoria, Kenya

S23 was isolated from saline soil of Lake Bogoria. Its draft genome, generated using Illumina HiSeq sequencing, comprises 5,583,771 bp across 205 contigs and contains 5,741 predicted protein-coding genes. Genome mining identified biosynthetic gene clusters associated with the pro...

Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice

Trained immunity enables innate immune cells to acquire memory-like responses, offering a strategy to enhance antitumor immunity. However, the metabolic‒epigenetic mechanisms underlying this process remain poorly defined. Here, we show that lipopolysaccharide-induced macrophage t...

Postbiotic mechanisms of long-term fermented soybean foods in host immunometabolic regulation: a critical appraisal of evidence, contradictions, and precision nutrition perspectives

Traditionally made long-term fermented soybean (LTFS) foods, including doenjang, miso, ganjang, and douchi, are produced through months to years of fermentation under high-salinity conditions (12-20% NaCl), generating convergent postbiotic profiles comprising free amino acids, is...