BioChem Technology (United States)

Systematic pathway engineering of Escherichia coli for enhanced 3’-sialyllactose production

3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient m...

Discovery of TL10:A Soluble and Long-Acting MC4RAgonist with Tunable Lipidation for Sustained Pharmacological Activity

Abstract The development of long-acting MC4R peptide agonists remains challenging due to rapid clearance and structural sensitivity, where conventional permanent lipidation strategies often impair receptor engagement. Here, we report the discovery and characterization of TL10, a...