Biobanking and Biomolecular Resources Research Infrastructure Consortium

Short telomeres, but not accelerated epigenetic or proteomic age, increase fibrotic lung disease risk: Mendelian randomisation with pleiotropy dissection and independent replication

Background. Short telomeres are an established cause of idiopathic pulmonary fibrosis (IPF), but the genetic evidence rests on seven instruments, six of which lie at telomere-maintenance loci, and so cannot separate an effect of telomere length from an effect of the telomerase pa...