Institution
Bio-Medical Science (South Korea)
Recent research
- Society & EconomicsOpen access
Evidica Evidence Manifest specification, version 0.1
An Evidence Manifest is a small, self-contained JSON record of how the claims in a manuscript are tied to specific passages in specific sources, and of the human decisions that made those ties. The researcher produces it from a local evidence workflow. It is a projection of the p...
- Health & MedicineOpen access
Abstract Background Lung cancer remains a leading cause of cancer-related death, and chemotherapy is often limited by systemic toxicity and insufficient drug accumulation in lung tumors. Inhalable nanomedicine offers a route to address these limitations, but nanoparticle systems...
- BiologyOpen access
Abstract We introduce the Serna Bio GenAI platform, a generative chemistry and multiparametric optimization platform for the design of RNA-targeting small molecules. Targeting RNA with small molecules has proven historically challenging but offers notable potential upsides, inclu...
- Health & MedicineOpen access
Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells
γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T-cell receptor (TCR), which is expressed by the predominant subset of γδ T cells, responds to phosphoantigen (pAg)-engaged butyrophilins (BTNs) on various cancer cells. However, the molecular mechanism...
- BiologyOpen access
Major depressive disorder (MDD) remains a critical global health burden, and a substantial proportion of patients exhibit insufficient responses to conventional monoaminergic antidepressants. Selective inhibition of the two-pore domain potassium channel TREK1 has emerged as a pro...