BG University Hospital Bergmannsheil Bochum

When trauma turns septic: Associated factors and focus-specific mortality in 61,399 patients from the TraumaRegister DGU®

PURPOSE: Sepsis is a critical complication after severe trauma. This study aimed to identify factors associated with sepsis, to characterise sepsis foci in relation to injury pattern, and to evaluate the association of sepsis with multiple organ failure (MOF) and in-hospital mort...

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 level...

Sensory data-driven classification of complex regional pain syndrome: a multicentre cohort study

BACKGROUND: The underlying pathophysiological mechanisms of complex regional pain syndrome (CRPS) have been under debate in recent years. Previous studies identified mechanistic CRPS subtypes, which were characterised as 'cold' and 'warm' or peripheral and central phenotypes. Our...