Betsi Cadwaladr University Health Board

Transcriptomic profiling of tropomyosin isoforms in bladder cancer: multi-platform sequencing and experimental validation

mRNA isoform level-based biomarkers are understudied but might complement DNA based approaches. The expression of tropomyosin isoforms differs between normal and cancer cells. Tropomyosin (TPM) isoforms generated by alternative splicing may contribute to Bladder Cancer (BC) biolo...

New Model of Care Achieving Micro‐Elimination of Hepatitis C in the United Kingdom's Largest Prison

Wales aims to achieve the World Health Organisation goal of eliminating hepatitis C (HCV) as a public health threat by 2030, with micro-elimination in prisons identified as a key target. In January 2022, HMP Berwyn, the largest prison in the United Kingdom, introduced a multi-dis...

The Rare dISease Evaluation (RISE) study: a survey-based investigation of medical student experience and knowledge of rare disease in the UK

Abstract Background Rare diseases are a significant public health concern, with over 6,000 diseases identified with an estimated collective point prevalence of 5.6–6.9%. People living with rare disease face numerous challenges within healthcare including prolonged time to diagnos...