Beneficência Portuguesa de São Paulo

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Intestinal permeability in allogeneic hematopoietic stem cell transplantation: A comprehensive review of measurement methods, clinical determinants and prognostic significance

The role of intestinal permeability in patients undergoing allogeneic hematopoietic stem cell transplantation remains unclear. This narrative review aimed to critically analyze the available evidence regarding the dynamics, predictors, and prognostic significance of intestinal pe...

Lean management in a low-digitalization context: implementing manual time and motion analysis in a public hospital emergency department

Purpose This study aims to describe the challenges and adaptive strategies involved in implementing a manual chronoanalysis instrument at the entrance of a medium-sized public emergency department in a nondigital context, from a Lean in Emergency Care perspective. Design/methodol...

Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection

Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SA...

Optimizing safety and efficacy of asparaginase and blinatumomab therapy in frontline acute lymphoblastic leukemia regimens in diverse health care settings—international expert consensus

Frontline blinatumomab combined with chemotherapy has resulted in improved outcomes in both pediatric and adult patients with acute lymphoblastic leukemia and is considered the new cornerstone of acute lymphoblastic leukemia treatment. The role of asparaginase in this new landsca...