Ben-Gurion University of the Negev

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Malignant hyperthermia (MH) is a life-threatening pharmacogenetic condition triggered by volatile anesthetics, which activate pathogenic RyR1 mutants. The small molecule therapeutic dantrolene has long been used to treat MH. However, the binding site and mechanism of dantrolene r...

Building Trust After Zero Trust: A Longitudinal Empirical Study of Organizational Trust Dynamics in Telecommunications Infrastructure

Telecommunications infrastructures are increasingly cloud-native, multi-vendor, and mission-critical environments, integrating 5G core networks, virtualized network functions, and software-defined infrastructure that expand the operational attack surface and make robust security...

IgG4-related endobronchial lung disease and HIV: a case report and review of the literature

Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disorder which typically presents as multiorgan infiltration by polyclonal IgG4-positive plasma cells and responds well to immunosuppression such as systemic corticosteroids. The co-occurrence of IgG4-RD among...

Gestational diabetes in multifetal versus singleton pregnancies: A multicenter cohort study

Abstract Introduction Gestational diabetes mellitus (GDM) is associated with increased neonatal morbidity in singleton pregnancies, but evidence in multifetal pregnancies is limited. Current diagnostic thresholds are largely extrapolated from singleton data; It remains unclear wh...

Connections: A Smarter Way to Target Influencers

Jacob Goldenberg, Andreas Lanz, Florian Stahl, and Daniel Shapira show that managers and creators who build ties with nearby, low-status influencers outperform those who cultivate high-status influencers. This efficient means of expanding audiences uses the existing dynamics of s...

Fungal necromass dominates soil organic carbon accrual after decadal active restoration of alpine grassland

Active (seeding native grasses) and passive (natural recovery via degradation factor removal) restoration practices regulate soil organic carbon (SOC) recovery in degraded grasslands through distinct mechanisms. We quantified microbial- (amino sugars) and plant-derived (lignin ph...

Anti-collinear resummation in JIMWLK evolution in the linear regime

A bstract The recently-proposed resummation procedure for anti-collinear logarithms in the JIMWLK kernel [1] is studied in the linear (BFKL) regime in the fixed-coupling approximation. Simple closed form expressions for the resummed momentum space kernel and characteristic functi...

Centralization vs. Decentralization: First Evidence from the Laboratory

The future architecture of financial systems is a subject of contention, with centralized and decentralized governance proponents. Here, we ask the following question. Would the architecture affect the quality of decision making? We propose a game where financial network particip...

Long-term population dynamics of a human-associated colonial raptor: Case of Lesser Kestrel Falco naumanni

Long-term monitoring is essential for understanding how demographic processes operating across generations, and under environmental stochasticity, shape population change. This is especially true in human-modified landscapes where nesting opportunities and food resources can shif...

Pregnancy after Hemithyroidectomy: Increased Risk of Gestational Overt Hypothyroidism Despite Favorable Obstetric Outcomes: A Nationwide Study

Background: To assess the association between preconception hemithyroidectomy and the risk of gestational hypothyroidism and obstetric outcomes. Methods: This nationwide population-based retrospective cohort study compared euthyroid pregnant women with a history of hemithyroidect...

P1.151. Management of Antral Adenocarcinoma 14 Years After Esophagectomy With Gastric Pull-Up: A Surgical Challenge

Abstract Topic Esophageal Cancer: Other Case Submission An 84-year-old male had previously undergone a three-field esophagectomy with gastric pull-up reconstruction for stage I adenocarcinoma of the distal esophagus 14 years earlier. He remained disease-free during long-term foll...

Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut‐Brain Interaction

OBJECTIVE: Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders....

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Individualized Prediction of Recurrence Following Uterine-Preserving Pelvic Organ Prolapse Repair Using Internally Validated Machine Learning Models

Background/Objectives: Approximately 11–20% of women affected by pelvic organ prolapse (POP) will undergo surgical intervention during their lifetime and nearly one-third of these women will require an additional procedure due to recurrence or failure of the initial repair. This...

Biogeochemical dichotomy and intra-order variability in Miliolid and Rotaliid foraminifera

Abstract. Foraminiferal geochemical records reflect both environmental and biological influences. Disentangling these factors is essential for improving their application in marine monitoring and contributing valuable insights into the evolution across major foraminiferal lineage...

Development and internal validation of the Low Cardiac Index Score: a simplified bedside tool for continuous intraoperative screening

<title>Abstract</title> Purpose Advanced haemodynamic monitoring of cardiac index is restricted to selected high-risk cases, leaving most patients undergoing major surgery without real-time assessment. We aimed to develop and internally validate a simplified bedside score for con...

A protein chaperone can stabilize the intein‐containing precursor to indirectly promote protein splicing

Abstract In tervening pro teins (inteins) interrupt host protein sequences and are removed by a self‐mediated protein splicing reaction. Inteins are abundant in the microbial world and are often found within essential genes involved in DNA replication, recombination, and repair....

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

ABSTRACT Purine crystals, such as guanine, generate diverse optical phenomena in animals and function as important nitrogen‐storage reservoirs in microalgae. Here, we demonstrate the formation of guanine crystals in Brewer's yeast. Whilst guanine crystals do not naturally contrib...

Fostering reflection: Development and initial evaluation of a mentalization-based GenAI simulator for foster care supervisors

Background Foster care supervisors require advanced reflective functioning (RF) to manage complex relational demands, yet traditional training is difficult to scale and access. Generative AI (GenAI) may help by enabling simulated practice environments. Objective This feasibility...

Knowledge design in complex domains

Traditional Knowledge Engineering (KE) often fails to address modern complex domains characterized by "wicked problems," where non-stationary ground truths and high dimensionality render static rule sets obsolete. This paper proposes a paradigm shift from traditional Knowledge En...