Beijing YouAn Hospital

Bone-targeting engineered exosomes delivering teriparatide mRNA for the treatment of osteoporosis

Introduction Teriparatide (TPTD) is an established osteoanabolic agent for the treatment of osteoporosis; however, its short circulating half-life necessitates repeated administration, while limited skeletal selectivity may reduce delivery efficiency. To address these limitations...

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT ‐Driven Metastasis in Triple‐Negative Breast Cancer

ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential and poor prognosis, yet the molecular mechanisms driving metastasis remain incompletely understood. Here, we performed integrated transcriptomic, metabolomic, and imaging mass cy...

Pathophysiological mechanisms and therapeutic strategies of hepatic ischemia–reperfusion injury

Abstract Hepatic ischemia–reperfusion injury commonly occurs in conditions such as trauma, shock, hepatectomy, and liver transplantation. In the absence of timely intervention, severe cases may progress to liver failure, significantly affecting patient prognosis and surgical outc...

Safety and satisfaction of voluntary medical male circumcision among men who have sex with men in China

PURPOSE: To investigate the safety and satisfaction of circumcision among men who have sex with men (MSM), as voluntary male medical circumcision (VMMC) may be an innovative and acceptable tool for HIV prevention among this population in the future. METHODS: Participants who volu...

Endoplasmic reticulum stress-mediated PPARα-DDX3X interaction promotes immune-induced liver injury

Dysfunction of endoplasmic reticulum (ER) stress is involved in the pathogenesis of immune-mediated liver injury, but its molecular mechanism has not been fully elucidated. This study explored PPARα-DDX3X interactions in regulating ER stress-related dysfunction. Liver injury was...

EAT Thickness and BAT-Related Thermogenesis: Dual Imaging Phenotypes Associated with Hepatic Steatosis Severity in MASLD

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with ectopic fat accumulation and alterations in adipose tissue function. However, the relationships of structural and thermogenic adipose imaging markers with hepatic steatosis remain inco...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

The combination of TLSs and the neutrophil-to- monocyte ratio predicts early recurrence in patients with hepatocellular carcinoma

Liver cancer, primarily hepatocellular carcinoma (HCC), is one of the deadliest cancers globally. However, effective predictive models for early recurrence and poor prognosis in HCC remain limited. This retrospective study analyzed 180 patients with HCC to explore the prognostic...

Deciphering the Roleof Hydrophobic Amino Acid l -Methionine in Tuning CO2 Hydrate Kinetics:Insights from Molecular Dynamics Simulations

Abstract CO2 clathrate hydrate has emerged as a promising medium for carbon sequestration owing to its exceptionally high CO2 storage capacity and intrinsic stability in subsea environments. Sluggish growth kinetics hinder its field application and large-scale deployment. The hyd...

HydrophobicDilauroyl Peroxide Improves the ElectricalPerformance and Stability of PTAA in both n-i-p andp-i-n Perovskite Solar Cells

Abstract Stability degradation plagues both regular n-i-p and inverted p-i-n perovskite solar cells (PSCs), with the organic hole transport layer (HTL) constituting a key restricting factor. Poly(triarylamine) (PTAA) possesses intrinsic polymer characteristics and excellent therm...