Beijing Shijitan Hospital

Bone-targeting engineered exosomes delivering teriparatide mRNA for the treatment of osteoporosis

Introduction Teriparatide (TPTD) is an established osteoanabolic agent for the treatment of osteoporosis; however, its short circulating half-life necessitates repeated administration, while limited skeletal selectivity may reduce delivery efficiency. To address these limitations...

Phantom-based accuracy validation of multimodal ultrasound and C-arm cone-beam CT image fusion for spine navigation

C-arm cone-beam computed tomography (CBCT) provides three-dimensional bony anatomy for spine navigation, whereas tracked ultrasound can provide local radiation-free anatomical information. Accurate fusion remains challenging because of ultrasound artifacts, incomplete surface vis...

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the...

Timing of transurethral laser enucleation of the prostate after transperineal prostate biopsy: a multicenter cohort study

The optimal timing of transurethral laser enucleation of the prostate after transperineal prostate biopsy (TPB) remains uncertain. This study evaluated whether the interval between TPB and subsequent transurethral laser enucleation influences perioperative outcomes and postoperat...

The “Five in One” integrated precise prevention and control system for pollen allergic diseases in Northern China: A narrative review with global perspective

Allergic diseases driven by airborne pollen are a growing public health burden in Northern China, where spring tree pollens and summer–autumn weed pollens are major triggers of allergic rhinitis, asthma, conjunctivitis, atopic dermatitis, and anaphylaxis. Internationally, managem...

WHR and adverse health outcomes: a prospective study on cancer incidence, all-cause and cancer-specific mortality

Obesity is a significant global public health issue, traditionally linked to adverse health outcomes. However, the “obesity paradox” suggests that in certain populations, obesity may be associated with better prognosis. This study investigates the relationship between waist-to-hi...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study

<title>Abstract</title> Background The optimal spontaneous breathing trial (SBT) strategy remains uncertain because commonly used approaches involve distinct physiological trade-offs. Pressure support ventilation (PSV) may underestimate the respiratory load after extubation, wher...