Beijing Obstetrics and Gynecology Hospital

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Vision-Language Model as a ‘Zero-Shot’ Assistant for Evaluating Condylar Osseous Changes in Cone-beam Computed Tomography

INTRODUCTION AND AIMS: Interpreting condylar osseous changes on CBCT is challenging for general practitioners. This study evaluated the 'zero-shot' diagnostic performance and utility of Vision-Language Models (VLMs) as AI assistants for detecting condylar abnormalities. METHODS:...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Factors associated with venous thromboembolism in ICU patients with sepsis: A retrospective analysis using the MIMIC-IV database

This study used the MIMIC-IV v3.1 database to examine factors associated with venous thromboembolism (VTE) in adult ICU patients with sepsis, excluding those with prior VTE or ICU stays under 48 h. Among 14,784 eligible patients, 1,038 (7.0%) developed VTE during their ICU stay....