Beijing Luhe Hospital Affiliated to Capital Medical University

Extracardiac CKM phenotypes and early cardiorenal-systemic mortality risk after acute myocardial infarction

Abstract Background Acute myocardial infarction (AMI) represents established cardiovascular disease within the cardiovascular-kidney-metabolic (CKM) continuum, yet outcomes after the acute event vary widely. We examined whether extracardiac metabolic, renal, inflammatory, and nut...

Safety and efficacy of Meridian sinew tuina (MST) for post-surgical upper limb lymphedema: a systematic review and meta-analysis

Background Complex Decongestive Therapy (CDT) is the non-operative standard for breast cancer-related lymphedema (BCRL), but many patients experience persistent subcutaneous stiffness, pain, and restricted mobility. This study systematically reviews the safety and clinical effica...

A five-phase evaluation framework for diagnostic and predictive medical artificial intelligence

Artificial intelligence (AI) has advanced rapidly across diagnostic, prognostic, and clinical decision-support applications, yet the pathway from laboratory performance to demonstrable clinical benefit remains fragmented and inconsistently defined. Existing evaluations rely heavi...

The probability of state transition of five diabetic complications and their influencing factors based on multi-state markov models: evidence from a Chinese cohort study

Diabetes-related complications remain a leading cause of disability and mortality among individuals with diabetes and substantially impair patients’ health-related quality of life. In this study, we employed a multi-state Markov model (MSM) to characterize transition probabilitie...

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Abstract Ischemic stroke (IS) is one of the primary causes of global mortality and permanent neurological disability, and its clinical treatment is severely constrained by the intricate ischemic pathological cascade and the impermeable blood‐brain barrier (BBB). Cerebral ischemia...

The Mechanism of Montelukast Sodium to Improve Inflammation in Ischemic Stroke: Based on Astroglia-Microglia Interactions

The present study aimed to elucidate the neuroprotective mechanism of montelukast sodium (MS) in ischemic stroke, with particular emphasis on astrocyte-microglia interactions. In vivo, adult male mice ( n = 10/group) were subjected to distal middle cerebral artery occlusion (dMCA...

Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study

<title>Abstract</title> Background The optimal spontaneous breathing trial (SBT) strategy remains uncertain because commonly used approaches involve distinct physiological trade-offs. Pressure support ventilation (PSV) may underestimate the respiratory load after extubation, wher...

The association between the availability of health guidance and self-management activities among patients with type 2 diabetes: a generalized linear mixed model incorporating patient- and GP-level factors

The availability of health guidance (AHG) provided by general practitioners (GPs) may vary in complex primary care settings. This study aimed to assess the AHG for patients with type 2 diabetes mellitus (T2DM) in general practice setting and examine the association between AHG an...

Pharmacokinetics, pharmacodynamics and safety profile of tapentadol hydrochloride injection: a phase 1 dose-escalation study in patients with moderate to severe pain

Abstract An injectable formulation of tapentadol hydrochloride offers a promising alternative for clinical settings requiring rapid analgesia. However, comprehensive clinical data on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of intravenous tapentadol hydrochlor...