Beijing Luhe Hospital Affiliated to Capital Medical University

The Mechanism of Montelukast Sodium to Improve Inflammation in Ischemic Stroke: Based on Astroglia-Microglia Interactions

The present study aimed to elucidate the neuroprotective mechanism of montelukast sodium (MS) in ischemic stroke, with particular emphasis on astrocyte-microglia interactions. In vivo, adult male mice ( n = 10/group) were subjected to distal middle cerebral artery occlusion (dMCA...

Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study

<title>Abstract</title> Background The optimal spontaneous breathing trial (SBT) strategy remains uncertain because commonly used approaches involve distinct physiological trade-offs. Pressure support ventilation (PSV) may underestimate the respiratory load after extubation, wher...

The association between the availability of health guidance and self-management activities among patients with type 2 diabetes: a generalized linear mixed model incorporating patient- and GP-level factors

The availability of health guidance (AHG) provided by general practitioners (GPs) may vary in complex primary care settings. This study aimed to assess the AHG for patients with type 2 diabetes mellitus (T2DM) in general practice setting and examine the association between AHG an...

Pharmacokinetics, pharmacodynamics and safety profile of tapentadol hydrochloride injection: a phase 1 dose-escalation study in patients with moderate to severe pain

Abstract An injectable formulation of tapentadol hydrochloride offers a promising alternative for clinical settings requiring rapid analgesia. However, comprehensive clinical data on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of intravenous tapentadol hydrochlor...