Beijing Jishuitan Hospital

Influenza A (H1N1) virus infection complicated by checkpoint inhibitor pneumonitis

Rationale: Checkpoint inhibitor pneumonitis (CIP) is a common, potentially severe adverse event in cancer patients receiving neoadjuvant immunotherapy, with glucocorticoids as the standard first-line treatment. Traditionally, glucocorticoids are avoided in confirmed viral pneumon...

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

Pimicotinib versus placebo in tenosynovial giant cell tumor (TGCT): a plain language summary of the MANEUVER clinical trial

Plain Language SummaryWhat is this summary about?This summary describes the main findings of the MANEUVER clinical trial for pimicotinib, a once-daily treatment. The goal was to see if pimicotinib could significantly reduce tumor size after 24 weeks of treatment in clinical trial...

Combined medial patellofemoral ligament reconstruction and distal femoral derotation osteotomy in recurrent patellar dislocation with Jumping J sign

Recurrent patellar dislocation (RPD) is commonly associated with patellar maltracking, and the Jumping J sign may indicate a severe instability phenotype. The optimal surgical strategy for patients with this sign remains unclear. The purpose of this study was to compare clinical...

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

ABSTRACT Severe muscle fat infiltration is a contributing factor to muscle loss, particularly in the spinal sarcopenia population. However, the underlying mechanism largely remains elusive. Here, we identified the intramuscular fat fraction (IMFF), rather than perimuscular fat fr...

Pathophysiological mechanisms and therapeutic strategies of hepatic ischemia–reperfusion injury

Abstract Hepatic ischemia–reperfusion injury commonly occurs in conditions such as trauma, shock, hepatectomy, and liver transplantation. In the absence of timely intervention, severe cases may progress to liver failure, significantly affecting patient prognosis and surgical outc...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

ABSTRACT Diabetic Foot Ulcer (DFU), a severe chronic diabetes complication with low healing and high recurrence rates, is a major global health challenge. Overexpression of matrix metalloproteinase‐9 (MMP‐9) and the consequent MMP‐9/TIMP1 (tissue inhibitor of metalloproteinase 1)...

Osteoclastogenesis with FN1-associated cell differentiation, immune communication, and ECM remodeling in male SAMP6 mice

Early diagnosis and precise treatment of senile osteoporosis remain challenging. Herein, we apply a multi-omics strategy, integrating scRNA-seq and proteomics in the male 5-month-old senescence-accelerated mouse prone 6 (SAMP6) spontaneous aging model, to study early bone loss. T...

Frailty and bone quality as the predictors of mechanical complications for patients after lumbar interbody fusion: a retrospective cohort study

Mechanical complications following lumbar interbody fusion are common in in elderly patients, particularly those with compromised bone quality. The MRI-based vertebral bone quality (VBQ) score assesses bone quality, while the modified frailty index (mFI) captures systemic physiol...

The prognostic value of resistin in patients with sepsis: a systematic review and meta-analysis

Sepsis remains a leading cause of mortality worldwide. Resistin, a pro-inflammatory cytokine secreted by monocytes and macrophages, has emerged as a potential biomarker of sepsis severity and prognosis. We systematically searched PubMed, EMBASE, Web of Science, and the Cochrane L...

An Optical Tracking‐Based Robot‐Assisted System for Spinal Fixation Rod Bending

ABSTRACT Background In spinal pedicle screw‐rod fixation, rod contouring quality influences insertion ease, construct stability, and corrective effect. Conventional bending relies on surgeon experience and is limited by insufficient support, repeated adjustment, and inefficient w...

Adjunctive posterior tibial tendon transfer during supramalleolar osteotomy for varus ankle osteoarthritis: a matched cohort study

The role of adjunctive posterior tibial tendon (PTT) transfer in supramalleolar osteotomy (SMO) for varus ankle osteoarthritis remains unclear. This study aimed to compare clinical and radiographic outcomes between SMO with adjunctive PTT transfer and isolated SMO, with particula...

Developing a health values framework for patients with cardiovascular-kidney-metabolic syndrome: a qualitative exploration through the lens of social determinants of health

Abstract Background Despite global calls for the advancement of patient-centered care, care planning often remains poorly aligned with patients’ lived social contexts and core values. This study aimed to understand what matters most to patients with cardiovascular-kidney-metaboli...

NIR‐Responsive CaMoO 4 /Mo 3 N 2 Heterojunction Modified Biomimetic Periosteum: Synergistic Anti‐Infection and Promotion of Bone Defect Repair

ABSTRACT Treating infected bone defects remains a formidable clinical challenge due to robust bacterial antioxidant resistance and severe microenvironmental deterioration. Herein, an antibacterial biomimetic periosteum (ABP) is rationally engineered by in situ anchoring ultrasmal...

LRCH4 drives tumor cell proliferation by regulating the GSK3B/MEK/ERK axis in colorectal cancer

Abstract Leucine-rich repeat-containing protein 4 (LRCH4), a member of the LRCH family, has emerged as a potential prognostic biomarker in several cancers, including colorectal cancer (CRC). While other proteins in this family have been implicated in tumorigenesis, the specific r...

Association between serum p-cresyl sulfate levels and cardiac valve calcification as well as prognosis in maintenance hemodialysis patients

Abstract Objective Cardiac valve calcification is a common complication in patients undergoing maintenance hemodialysis, and is closely linked to adverse clinical outcomes. P -cresyl sulfate, a typical protein-bound uremic toxin, has been implicated in the pathogenesis of vascula...

Impact of combined medial and lateral bone marrow lesions on clinical outcomes after medial unicompartmental knee arthroplasty

Aims Although the influence of medial bone marrow lesions (BMLs) on outcomes after medial unicompartmental knee arthroplasty (UKA) has been studied, the impact of concomitant lateral compartmental BMLs remains unclear. This study aims to determine whether the lateral BMLs, in add...

Patellar fixation in MPFL reconstruction: a network meta-analysis comparing bone tunnel and suture anchor techniques

Although medial patellofemoral ligament (MPFL) reconstruction has become the cornerstone procedure for recurrent patellar instability (RPI), the optimal patellar-side fixation technique remains debated. Direct head-to-head comparisons are scarce, and traditional pairwise meta-ana...

Mechano‐Electrical Coupling Scaffold Drives Bone Organoids Bioenergetic Reprogramming to Accelerate Bone Regeneration

ABSTRACT Critical‐sized bone defects remain a major clinical challenge in orthopedics and regenerative medicine. Bone organoid provided therapy potentials; however, current engineering strategies generally neglect the bioenergetic foundation and intrinsic mechano‐electrical coupl...