Beijing Institute of Neurosurgery

circRNADisease v3.0: an updated resource for high-quality, experimentally supported circRNA-disease associations.

Systematic integration of circular RNA (circRNA)-disease associations is essential for elucidating the roles of circRNAs in disease pathogenesis and evaluating their potential as biomarkers and therapeutic targets. circRNADisease was established as a manually curated database of...

Early Risk Stratification and Time-to-Cure Analysis in Patients with Residual Hemifacial Spasm After Microvascular Decompression

Background/Objectives: Microvascular decompression (MVD) is an effective treatment for hemifacial spasm (HFS), but some patients have residual spasms after surgery. Some later achieve delayed cure, whereas others have persistent HFS, making reoperation planning difficult. This st...

Efficacy and Safety of Stent-Assisted Coiling Versus Coiling Alone for Ruptured Multilobed Aneurysms: A Multicenter Study

BACKGROUND: Ruptured multilobed intracranial aneurysms present significant procedural challenges and high recurrence risks in endovascular treatment due to complex geometry and turbulent hemodynamics. Currently, the safety and long-term efficacy of stent-assisted coiling (SAC) ve...

Terahertz-based prognostic framework for glioma: from spectral features to patient-level prognostic assessment

In glioma, accurate prediction of recurrence and survival is essential for clinical decision-making and individualized management. However, current prognostic tools do not fully capture outcome heterogeneity, and convenient approaches for early postoperative prognostic evaluation...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...