Beijing Institute of Genomics

Receptor-binding geometry constrains viral antigenic evolution through fitness-evasion coupling

Although viral antigenic evolution is shaped by the competing demands of immune evasion and receptor-binding fitness, the physical principles underlying divergent viral evolutionary dynamics remain poorly understood. Here, by integrating structural biology, deep mutational scanni...

Sleep quality is associated with gut microbiome signatures of hyperuricemia in Chinese elderly adults: a community-based case–control study

Hyperuricemia (HUA) has become a global health issue due to its rapidly increasing prevalence. Growing evidence from population and animal studies suggests that gut microbial dysbiosis and lifestyle changes are involved in serum uric acid metabolism. However, most existing studie...

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos

Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest...