Beijing Hospital

Bone-targeting engineered exosomes delivering teriparatide mRNA for the treatment of osteoporosis

Introduction Teriparatide (TPTD) is an established osteoanabolic agent for the treatment of osteoporosis; however, its short circulating half-life necessitates repeated administration, while limited skeletal selectivity may reduce delivery efficiency. To address these limitations...

Commutability Assessment of Materials for Serum Copper Measurement Using the IFCC Difference-in-Bias and the CLSI EP30 Approaches

Background: Evidence on the commutability of material for serum copper when assessing multiple material categories and assay pairs remains limited. Methods: We evaluated 21 reference materials for serum copper across four routine colorimetric systems and an inductively coupled pl...

Shared oral microbiome signatures linking periodontitis and autoimmune thyroiditis: NHANES 2009–2012

Objective To examine the association between periodontitis severity and autoimmune thyroiditis (AIT) in a nationally representative US sample and to explore oral microbiome features shared between the two conditions.Methods We analyzed adults from NHANES 2009–2012 with complete p...

Residual lipid-related proteomic and metabolomic signatures associated with major adverse cardiovascular events after revascularization in peripheral artery disease

Patients with peripheral artery disease (PAD) remain at high risk for major adverse cardiovascular events (MACE) after lower-extremity revascularization. In contemporary practice, widespread lipid-lowering therapy may reduce the discriminatory value of conventional lipid paramete...

Multicenter evaluation of Coyote FlashDetect LyocartE multiplex assays for six respiratory pathogens: a comparative analysis with Sansure and Cepheid assays

ABSTRACT Respiratory diseases caused by common respiratory pathogens, such as influenza A/B (Flu A/B), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumoniae (MP), share many of the same symptom...