Beijing Geriatric Hospital

Cerebellar Glutamate Chemical Exchange Saturation Transfer Alterations Correlated With Cognitive Impairment in Parkinson's Disease

ABSTRACT The role of cerebellar glutamatergic dysfunction in cognitive impairment of Parkinson's disease (PD) remains poorly understood. Glutamate chemical exchange saturation transfer (GluCEST) imaging enables noninvasive assessment of regional glutamate levels. To investigate t...

Association of metformin use with vitamin B12 deficiency and peripheral neuropathy in type 2 diabetes mellitus: a systematic review and meta-analysis

Abstract Background Metformin is the first-line pharmacological therapy for type 2 diabetes mellitus (T2DM). However, long-term use has been associated with reduced serum vitamin B12 levels, which may contribute to peripheral neuropathy — a common and debilitating complication of...

Is Higher α-Linolenic Acid Content Preferable? Assessing Digestive Fate of Flaxseed Oil in In Vitro Digestion Models of Infants, Adults and the Elderly

α-Linolenic acid (ALA) is an essential omega-3 polyunsaturated fatty acid, yet how dietary ALA enrichment interacts with population-specific gastrointestinal physiology to dictate bioaccessibility and lipid peroxidation remains insufficiently understood. This study systematically...

Severe skeletal and renal complications in SLC4A1-related distal renal tubular acidosis following prolonged treatment interruption: a case report highlighting transition-related vulnerability

Abstract Background SLC4A1-related distal renal tubular acidosis (dRTA), caused by dysfunction of the anion exchanger 1 (AE1), is typically associated with a relatively mild and late-onset phenotype. However, outcomes may vary substantially, particularly in the setting of delayed...