Beijing Ditan Hospital

QHHP Ameliorates MASH Through Modulation of a Cyp4a32–PPARγ–CD36‐Associated Lipotoxic Axis

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive stage of metabolic dysfunction-associated fatty liver disease, for which effective pharmacological therapies remain limited. Qinggan Huatan Huoxue Prescription (QHHP) has been used clinically in the manageme...

Bone health trajectories following regimen optimization in male people living with HIV receiving TDF: a prospective, observational, cohort study

TDF exposure is associated with reduced bone mineral density (BMD) in people living with HIV (PLWH). Data remain limited evaluating changes in BMD and bone turnover markers (BTMs) after switching to tenofovir alafenamide (TAF), TDF/TAF-free regimens such as dolutegravir/lamivudin...

Quality verification of hepatitis C surveillance data in a high-volume tertiary center in Chaoyang District, Beijing, 2023

To assess the current status of hepatitis C case reporting quality at a designated hepatitis C treatment institution in Chaoyang District, Beijing, identify problems in data reporting, standardize the reporting practices of the study institution, and provide evidence for improvin...

The enhanced importance of CD4+ T cell based monitoring of microbial flora in patients with HIV

Individuals infected with human immunodeficiency virus (HIV) frequently display diminished CD4 + T Cell levels, heightening susceptibility to diverse infections and imposing substantial burdens alongside life-threatening risks. This study aimed to compare lung microbial communiti...

sTREM2 and GFAP mediated the association of cerebrospinal fluid GLP-1R with tau pathology in alzheimer’s disease

Glucagon-like peptide-1 receptor (GLP-1R) is involved in metabolic regulation and has also been implicated in neuroprotection and the modulation of neuroinflammatory processes in the central nervous system. GLP-1R has therefore emerged as a potential therapeutic target for Alzhei...

Rickettsia japonica strain YC21 from a fatal human case in China: comparative genomics and experimental characterization of infection phenotypes

Rickettsia japonica causes Japanese spotted fever (JSF), an emerging severe tick-borne disease in East Asia. We recently isolated strain YC21 from the first laboratory-confirmed fatal JSF case in China. This study aimed to characterize the genomic features and infection phenotype...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

ABSTRACT Growth hormone–secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed RNA sequenc...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Brain rare metastatic tumors: a clinicopathological analysis of 14 cases

As one of the most common types of malignant brain tumors, brain metastases are associated with poor clinical outcomes. Lung cancer, breast cancer, colorectal cancer, and renal cell carcinoma are the most frequent primary tumors causing brain metastases. This study explores the c...