Beijing Chao-Yang Hospital, Capital Medical University

Long-term clinical and radiographic outcomes of interlaminar coflex dynamic stabilization versus posterior lumbar interbody fusion for lumbar spinal stenosis: a comparative study with minimum 15-year follow-up

This study aimed to evaluate the clinical and radiographic outcomes of inter-laminar Coflex dynamic stabilization compared with posterior lumbar interbody fusion (PLIF) for the treatment of lumbar spinal stenosis (LSS) over a long-term follow-up period exceeding 15 years. A retro...

CURB-65 score for predicting deep vein thrombosis in severe community-acquired pneumonia: a cohort study

Patients with severe community-acquired pneumonia (SCAP) are at significantly increased risk for venous thromboembolism (VTE). Traditional VTE risk assessment tools like the Caprini and Padua prediction scores are often underutilized in acute care settings due to their complexity...

A de novo IKZF4 Variant Underlies Hypogammaglobulinemia and Increased Infection Susceptibility through Downregulating the NF-κB Pathway

Inborn errors of immunity (IEI) are a group of complex diseases characterized by reduced immunity and increased susceptibility to external pathogens, autoinflammation, autoimmune conditions, and/or malignancy. The IKAROS zinc-finger ( IKZF ) family is a group of C2H2 zinc-finger...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Longitudinal profiling of upper respiratory tract microbiota and metabolome in hospitalized COVID-19 convalescents: a 3-year prospective cohort study

Long COVID is characterized by persistent, far-reaching effects in convalescent individuals, with pulmonary diffusion impairment emerging as a clinically impactful sequela affecting more than one-third of this population. The salivary microbiome and metabolome, reflecting the ora...

Application of a machine learning model integrating T cell subsets and clinical markers in 28-Day mortality prediction of sepsis patients

To develop a machine learning-based prediction model that integrating T cell subset data with clinical features to predict the 28-day mortality risk in sepsis patients. A retrospective cohort study was conducted using the MIMIC-IV database. Collected data included demographics, T...