Beijing Chao-Yang Hospital, Capital Medical University

Synergistic effects of cerebrovascular reactivity and gray matter volume on executive function in aging

Background Age-related impairments in cerebrovascular reactivity (CVR) and gray matter volume (GMV) both contribute to cognitive decline, yet their regional interplay and joint impact on cognition remain unclear. Objective To investigate how CVR and GMV are coupled and interact r...

Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose

AIMS: This study aimed to examine the associations of maternal first-trimester atherogenic index of plasma (AIP) with gestational diabetes mellitus (GDM) and birth weight outcomes, and the mediating role of second-trimester blood glucose. METHODS: [TG (mg/dL)/HDL-C (mg/dL)] from...

Effect of thoracic paravertebral block with liposomal bupivacaine on quality of recovery after video-assisted thoracic surgery: a randomized controlled trial

Abstract Background The effect of thoracic paravertebral block with liposomal bupivacaine on recovery after video-assisted thoracic surgery remains uncertain. Methods This single-centre, double-blind, randomized controlled trial enrolled ninety adults aged 18 to 65 years who were...

Development and external validation of prediction models for a trial-informed operational composite after stage 3 acute kidney injury

Renal replacement therapy (RRT) is considered when severe acute kidney injury (AKI) is complicated by severe electrolyte disturbance, acid-base derangement, fluid overload with respiratory compromise, or azotaemia. However, actual RRT initiation is influenced by clinician and cen...

Proteasome subunit-based biomarker panel for early diagnosis of acute respiratory distress syndrome and therapeutic targeting of PSMB8 in a mouse model

Acute respiratory distress syndrome (ARDS) remains a leading cause of mortality in intensive care units worldwide. Timely diagnosis and targeted treatment are critical for significantly improving patient outcomes. Plasma proteomics from 196 patients with ARDS, 100 non-ARDS pulmon...

Multicenter evaluation of Coyote FlashDetect LyocartE multiplex assays for six respiratory pathogens: a comparative analysis with Sansure and Cepheid assays

ABSTRACT Respiratory diseases caused by common respiratory pathogens, such as influenza A/B (Flu A/B), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumoniae (MP), share many of the same symptom...

Comparison of SIS-reinforced anastomosis and conventional anastomosis on postoperative AL for middle and low rectal cancer: a study protocol for multicenter randomized controlled clinical trial

Postoperative anastomotic leak (AL) remains a major complication after radical resection of middle and low rectal cancer. Current preventive strategies, such as the creation of a diverting ostomy, effectively mitigate clinical complications. However, they are associated with cons...

Association Between Brain Natriuretic Peptide and Intradialytic Hypotension in Hemodialysis Patients: A Retrospective Study

Background: Intradialytic hypotension (IDH) is a common complication of hemodialysis (HD) and is associated with an increased risk of poor prognosis. This study investigated the factors associated with IDH in HD patients and explored the value of brain natriuretic peptide (BNP) i...

Association of sarcopenia and longitudinal changes in sarcopenia status with all-cause mortality in individuals with cardiovascular-kidney-metabolic syndrome

We investigated the associations of sarcopenia, handgrip strength (HGS), appendicular skeletal muscle mass index (ASMI), and longitudinal changes in sarcopenia status with all-cause mortality among middle-aged and older adults aged ≥ 50 years with cardiovascular-kidney-metabolic...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

Development, validation, and visualization of a CT-based predictive model for pedicle screw loosening risk after posterior lumbar fusion

This study aimed to develop and validate a visualization-based predictive model for evaluating the risk of pedicle screw loosening (PSL) following posterior lumbar interbody fusion (PLIF) in patients with lumbar degenerative conditions. A total of 466 consecutive patients undergo...

Long-term clinical and radiographic outcomes of interlaminar coflex dynamic stabilization versus posterior lumbar interbody fusion for lumbar spinal stenosis: a comparative study with minimum 15-year follow-up

This study aimed to evaluate the clinical and radiographic outcomes of inter-laminar Coflex dynamic stabilization compared with posterior lumbar interbody fusion (PLIF) for the treatment of lumbar spinal stenosis (LSS) over a long-term follow-up period exceeding 15 years. A retro...

CURB-65 score for predicting deep vein thrombosis in severe community-acquired pneumonia: a cohort study

Patients with severe community-acquired pneumonia (SCAP) are at significantly increased risk for venous thromboembolism (VTE). Traditional VTE risk assessment tools like the Caprini and Padua prediction scores are often underutilized in acute care settings due to their complexity...

A de novo IKZF4 Variant Underlies Hypogammaglobulinemia and Increased Infection Susceptibility through Downregulating the NF-κB Pathway

Inborn errors of immunity (IEI) are a group of complex diseases characterized by reduced immunity and increased susceptibility to external pathogens, autoinflammation, autoimmune conditions, and/or malignancy. The IKAROS zinc-finger ( IKZF ) family is a group of C2H2 zinc-finger...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Longitudinal profiling of upper respiratory tract microbiota and metabolome in hospitalized COVID-19 convalescents: a 3-year prospective cohort study

Long COVID is characterized by persistent, far-reaching effects in convalescent individuals, with pulmonary diffusion impairment emerging as a clinically impactful sequela affecting more than one-third of this population. The salivary microbiome and metabolome, reflecting the ora...

Application of a machine learning model integrating T cell subsets and clinical markers in 28-Day mortality prediction of sepsis patients

To develop a machine learning-based prediction model that integrating T cell subset data with clinical features to predict the 28-day mortality risk in sepsis patients. A retrospective cohort study was conducted using the MIMIC-IV database. Collected data included demographics, T...