Beijing Center for Disease Prevention and Control

Accurate β-Casein Allergen Quantification in Processed Foods via an Isotope-Labeled Full-Length Protein Internal Standard

Abstract Accurate quantification of cow’s milk allergens in processed foods by UPLC-MS/MS is challenged by enzymatic digestion variability and complex matrix effects. β-Casein, a major milk allergen, requires reliable quantification. Herein, we developed a novel method for quanti...

Sleep quality is associated with gut microbiome signatures of hyperuricemia in Chinese elderly adults: a community-based case–control study

Hyperuricemia (HUA) has become a global health issue due to its rapidly increasing prevalence. Growing evidence from population and animal studies suggests that gut microbial dysbiosis and lifestyle changes are involved in serum uric acid metabolism. However, most existing studie...

A Dual-Key Lock Strategy for Bright Fluorescent Proteins Fabrication via Synergistic Noncovalent Activation of Aggregation-Induced Emission Luminogen

Abstract The development of simple, bio-friendly strategies to engineer bright fluorescent proteins (FPs) is crucial for biosensing and bioimaging. Conventional synthesis of FPs requires time-consuming chromophore maturation and tedious preparation, while covalent conjugation met...

Detection and Distribution of Tick-Borne Bacterial Pathogens in Ticks from Different Hosts in the Altun Mountains, China

Background: Ticks are the main vectors for a variety of tick-borne bacterial pathogens. Systematic studies on the coinfection patterns and differences of pathogens in ticks derived from different hosts are of great significance. Therefore, the present study investigated ticks col...