Beijing Anding Hospital

Dynamic negative symptom networks following personalized iTBS in schizophrenia

Background Negative symptoms are clinically heterogeneous and may be represented as interacting symptom domains. Whether personalized intermittent theta-burst stimulation (iTBS) is associated with changes in contemporaneous or temporal associations among negative-symptom domains...

Biosynthetic DNA origami nanostructures: harnessing E. coli-phage systems as nanofactories

DNA origami nanostructures (DONs) serve as versatile nanocarriers with promising application potential, but high production cost and low yield limit their development. The biosynthetic approach based on the Escherichia coli ( E. coli )-phage system offers an effective route for t...

Development and validation of the Beliefs in Social Anxiety Scale (BIAS) for Chinese socially anxious adults and adolescents

BACKGROUND: Maladaptive social beliefs play a pivotal role in the development and maintenance of social anxiety; however, existing measures have limited cultural adaptability for Chinese populations. Therefore, this study developed and validated the Beliefs in Social Anxiety Scal...

Interpretable speech biomarkers of psychological resilience in major depressive disorder via expert-guided large language models

Abstract Background Major depressive disorder (MDD) is highly prevalent and recurrent, but current clinical care focuses mainly on symptom reduction, overlooking the individual’s capacity for psychological resilience which is a key factor for long-term recovery. Traditional resil...

Toward precision psychiatry: integrating pharmacogenomics and multimodal clinical data for personalized antidepressant response prediction

Individual responses to antidepressant treatment are highly heterogeneous, resulting in prolonged trial-and-error processes that undermine clinical outcomes. Pharmacogenomics (PGx) holds substantial promise for advancing precision psychiatry by guiding personalized antidepressant...

Early Changes in Composite Insulin-Resistance Indices After Adjunctive Probiotic Treatment in Olanzapine-Treated Schizophrenia: A Longitudinal Secondary Analysis

Objective Olanzapine is effective for schizophrenia but commonly causes metabolic dysregulation. This study examined whether adjunctive probiotic treatment was associated with short-term changes in composite insulin-resistance-related indices during olanzapine therapy. Methods Th...

Real-world analysis of depression-related adverse events associated with the adsorbed anthrax vaccine: integrating pharmacovigilance signals, machine learning risk prediction, and transcriptomic mechanisms

Abstract Background Anthrax remains a life-threatening zoonotic disease in resource-limited settings. Adsorbed anthrax vaccine (AVA, BioThrax) is the only United States-authorized preexposure prophylaxis for high-risk Bacillus anthracis exposure. Although AVA safety has been desc...