Beaumont Hospital, Royal Oak

A DIAMETER AND HEMODYNAMIC REGULATION MODEL UTILIZING AN ARTERIOLAR NETWORK STRUCTURAL MODEL AND EXPERIMENT-BASED MACHINE LEARNING

Arteriolar regulation is central to maintaining adequate tissue perfusion, and its disruption can lead to adverse health outcomes. However, mechanisms governing vessel responses to complex environmental conditions within a network context remain uncertain. This study presents com...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Penetrating dural venous sinus injury: a scoping review of clinical presentation, operative management, and prognosis

Penetrating injury to the dural venous sinuses (DVS) commonly occurs at the superior sagittal sinus (SSS), transverse sinus (TS), and torcular confluence. While rare, DVS penetrating injuries carry high risk of intracranial hemorrhage, air embolism, and venous infarction. The cur...

Locoregional and systemic adoptive cellular therapies for pediatric brain tumors: a systematic review of CAR‑T, TCR‑engineered T cells, and NK cell strategies

Adoptive cellular therapies may expand treatment options for pediatric brain tumors by focusing activity on tumor antigens and limiting off-tumor effects. We systematically reviewed preclinical and clinical evidence for CAR T cells, TCR-engineered T cells, and NK or γδ T-cell pla...