Baylor University Medical Center

Postoperative Wound Care in Mohs Micrographic Surgery: Tradition, Variation, and the Evidence

ABSTRACT Postoperative wound care following Mohs micrographic surgery (MMS) has high variability and surprisingly limited real‐world evidence. Despite over one million MMS procedures performed annually in the United States, recommendations for topical agents, pressure dressings,...

Intra-abdominal Versus Descending Thoracic Cannulation Techniques for Abdominal Normothermic Regional Perfusion.

Background: Abdominal normothermic regional perfusion (A-NRP) is postmortem perfusion of organs in the abdominal cavity and can be performed using multiple approaches, including femoral, intra-abdominal, and thoracic. Our program began with surgeons performing intra-abdominal can...

Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...

Neuroimmune Phenotyping as the Next Frontier in Chronic Pain Medicine for Musculoskeletal Back Pain

Chronic low back pain encompasses heterogeneous mechanical, neuropathic, nociplastic, and myofascial presentations that may reflect distinct neuroimmune mechanisms. We synthesized evidence linking these phenotypes to measurable biological features and clinically relevant treatmen...

Hospital Admission Despite Low-Risk History, Electrocardiogram, Age, Risk factors, and Troponin (HEART) Scores and 30-Day Outcomes in Emergency Department Chest Pain

Objective To evaluate whether hospital admission of emergency department (ED) patients despite low-risk History, Electrocardiogram, Age, Risk factors, and Troponin (HEART) scores (<4) identifies a subgroup at higher risk for 30-day major adverse cardiovascular events (MACE) and t...

Elacestrant in Combination with Everolimus for Estrogen Receptor-Positive, HER2-Negative Previously Treated Advanced Breast Cancer: Results from ELEVATE

PURPOSE: Treatment options for progression on first-line endocrine therapy (ET)+CDK4/6i for ER-positive/HER2-negative (ER+/HER2-) advanced breast cancer (ABC) include ET plus targeted agents (CDK4/6i or PI3K/AKT/mTOR-pathway inhibitors). Elacestrant is the first single-agent oral...

Postoperative Complications Following Total Knee Arthroplasty in Patients with Chronic Lymphocytic Leukemia

Background/Objectives: Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, predominantly affects the aging population. With improved survival from modern targeted therapies, a growing number of CLL patients are living long enough to become candidates for quali...

Extended haplotypes at the complement factor H gene locus are associated with liver transplant rejection.

BACKGROUND: Acute T-cell-mediated rejection (ACR) remains an important complication after liver transplantation. Polymorphisms in the factor H gene (CFH) and factor H-related protein genes (CFHRs) affect the risk of multiple complement-related diseases. Given the complement syste...

Probiotic-Associated Invasive Infection Among Preterm Infants

This cohort study examines the incidence of invasive bacterial infection associated with probiotic supplementation among preterm infants.