Barts Health NHS Trust

Imaging-based biological age estimation predicts competing mortality risk in lung cancer screening

Abstract Lung cancer screening (LCS) participants have a high competing risk of non-lung cancer related death, which limits screening benefit. We hypothesized that imaging-based biological age can identify individuals at higher risk of non-lung cancer mortality. Low dose computed...

Predictive Models of Morbidity and Mortality in Gynaecological Cancer Surgery: A Systematic Review

Background/Objectives: Gynaecological–oncological surgery involves substantial perioperative morbidity and mortality risks. Reliable preoperative risk stratification could inform consent, shared decision-making and perioperative optimisation. Several prediction models exist, but...

Tissue-level implants in the aesthetic zone: why and how?

Tissue-level (TL) implants, originally developed to eliminate the need for a second surgical procedure, are increasingly being used in the aesthetic zone due to their unique design advantages. The vertical platform shift positions the implant-abutment junction coronally, minimisi...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Early national comparison of robotic versus conventional hip replacements for arthritis using National Joint Registry data: target trial emulation study

Abstract Objectives To evaluate the early comparative effectiveness of robotic versus conventional total hip replacement (THR) in the UK. Design Target trial emulation study. Setting Public and private hospitals using data from the National Joint Registry of England, Wales, North...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Association Between Genetic Ancestry and Multiple Sclerosis Severity

OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyp...

Predicting the Unpredictable: Development and External Validation of the GO SOAR Surgical Risk Calculator for Data-Driven Predictions of Surgical Complications in Gynaecological Oncology Surgery

Background/Objectives: Universal surgical risk calculators are not validated for use and poorly predict postoperative morbidity and mortality for women undergoing gynaecological oncology surgery. This adversely affects communication of risk resulting in poorly informed decisions...

‘Africans Against Malaria’—introducing a new diaspora-led initiative to strengthen malaria prevention amongst UK-based travellers visiting friends and relatives in malaria-endemic African countries

Use of malaria prevention methods, particularly chemoprophylaxis, amongst the UK-based African diaspora is low; a long-standing issue that remains inadequately addressed. Here, we present ‘Africans Against Malaria’, a unique initiative ‘led by Africans, for Africans’ to improve m...

Acceptability of advanced monitoring for acute respiratory failure requiring non-invasive respiratory support: A qualitative study of perceptions from patients and critical care practitioners

Background Advanced monitoring instruments can provide detailed assessment of work of breathing in patients with acute hypoxaemic respiratory failure (AHRF) managed with non-invasive respiratory support (NRS). Despite increasing availability, uptake in routine clinical practice r...

Association between preoperative radiographic osteoarthritis severity and patient-reported outcomes after total hip arthroplasty: a systematic review and meta-analysis

Abstract Purpose Although total hip arthroplasty (THA) reliably improves pain and function in patients with hip osteoarthritis (OA), a subset of patients experience limited postoperative benefit. The association between preoperative radiographic OA severity and postoperative pati...

Impact of high temperatures on healthcare utilisation among older adults: a scoping review

Abstract Background Rapid global ageing coincides with rising temperatures and increasing strain on healthcare services. High temperatures are associated with increased healthcare demand, yet evidence on older people’s healthcare utilisation remains fragmented and is often servic...

Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate

Abstract Objective Noninvasive microstructure estimates using magnetic resonance imaging (MRI) show potential in improving prostate cancer (PCa) diagnosis; however, histological validation is necessary. Materials and methods We used data from the Histo-MRI trial (NCT04792138). Pa...

Psychological, social, and ethical implications of population-based genetic testing among adults: a systematic scoping review protocol with a focus on cancer

The standard clinical genetic testing model for hereditary cancers applies stringent eligibility criteria and consistently misses large numbers of at-risk cancer-susceptibility-gene (CSG) carriers in the general population, leading to missed opportunities for cancer screening/pre...

FPHC Wellbeing: pregnancy, maternity and return-to-work guidelines

Introduction: In 2022, the Faculty of Pre-hospital Care (FPHC) report on ‘Valuing staff, valuing patients’ was published, outlining the need to ‘seek out and remedy secondary stressors’, such as training burdens or financial costs. As part of developing an FPHC well-being charter...

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) rem...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...