Institution
Barrow Neurological Institute
Recent research
- BiologyOpen access
Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...
- Health & Medicine
Inclusion of Robotics Versus Conventional Therapy
Date presented: April 24, 2026 Primary Author and Speaker: Kristin Palmiscno, kristin.palmiscno@commonspirit.org
- Health & Medicine
The silent pandemic: the overlooked toll of stroke compared to COVID-19
The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...
- Health & MedicineOpen access
BACKGROUND/HYPOTHESIS: Poor sleep quality is frequently reported among patients with cerebral small vessel disease (CSVD), but its neurovascular correlates remain unclear. We examined exploratory associations between multidomain neurovascular network (NVN) measures and poor sleep...
- Society & EconomicsOpen access
Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.
Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...
- BiologyOpen access
Abstract Neuroinflammation is associated with depression and anxiety risk, both of which demonstrate a bilateral relationship with cardiometabolic disorders. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is, thus, unclear whether...
- BiologyOpen access
Neurodegeneration and inflammation in a novel spinocerebellar ataxia 13 preclinical model
Abstract Neuroinflammation is a critical pathological feature underlying neurodegenerative diseases. Spinocerebellar ataxia 13 (SCA13) is a heterogeneous ataxia with several allelic variations of differing phenotypes. All are neurodegenerative and currently without effective trea...
- Health & Medicine
Background: While the global neurosurgical burden is highest in low- and middle-income countries, scientific output remains dominated by high-income nations. Paraguay has seen a dramatic seven-fold increase in its neurosurgical workforce since 1980, yet its academic footprint rem...
- Health & Medicine
BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...
- Health & Medicine
Amyloid-targeted monoclonal antibody therapies have introduced a new era in the treatment of early Alzheimer disease. However, their use has increased the importance of detecting and monitoring amyloid-related imaging abnormalities (ARIA) on MRI, as such findings may influence tr...
- Health & MedicineOpen access
A Case of a 40‐year‐old Female with Speech Disturbance
A 40-year-old Caucasian female with a history of migraines and depression presented to the emergency department for word-finding difficulty, speech disturbances, and “feeling off” for two days. Her husband reported that it sounded like she had a lisp when she spoke. She endorsed...
- BiologyOpen access
Microglial GRB2 is essential for brain ventriculogenesis and CSF homeostasis
Microglia play essential yet poorly understood roles in brain development, including axon guidance, regulation of neurogenesis, and pruning of neuronal projections. Congenital hydrocephalus (CH), characterized by enlarged cerebrospinal fluid (CSF)-filled ventricles, is a leading...
- Health & MedicineOpen access
Abstract INTRODUCTION: Research on the potential role of cardiometabolic diseases (CMDs) as risk factors for Lewy body dementia (LBD) is limited, and findings from existing studies remain inconclusive. We investigated the geospatial patterns of CMDs and the association with LBD a...
- Health & MedicineOpen access
Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...
- Health & MedicineOpen access
Functional Activity of TDP-43: A Direct Biomarker for ALS
TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...
- Health & MedicineOpen access
Background Population ageing is driving a global surge in cognitive impairment. While late-life decline is well-characterized, the onset of measurable cognitive changes across the full adult lifespan remains uncertain. We aimed to estimate the age at which detectable decline begi...
- Engineering & Technology
BACKGROUND: Assistive technology offers an important means of compensating for lost upper extremity function in adults with progressive neuromuscular diseases (NMD), enabling participation in daily activities, supporting independence, and promoting quality of life. However, the r...
- AI & Computing
BACKGROUND AND OBJECTIVES: Evaluating citation-based scholarly influence among academic faculty is foundational to academic medicine, as retention, promotion, and tenure to govern career advancement at every level. The h-index has been the standard metric across fields, including...