Barrow Neurological Institute

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Functional Activity of TDP-43: A Direct Biomarker for ALS

TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...

Timing of cognitive decline onset and life-course trajectories A pooled longitudinal analysis of 14,389 adults across three cohorts

Background Population ageing is driving a global surge in cognitive impairment. While late-life decline is well-characterized, the onset of measurable cognitive changes across the full adult lifespan remains uncertain. We aimed to estimate the age at which detectable decline begi...

Enabling Functional Independence: A Scoping Review of Upper Extremity Assistive Devices for Adults With Progressive Neuromuscular Diseases

BACKGROUND: Assistive technology offers an important means of compensating for lost upper extremity function in adults with progressive neuromuscular diseases (NMD), enabling participation in daily activities, supporting independence, and promoting quality of life. However, the r...

Evaluation of the Relative Citation Ratio Versus the H-Index as Measures of Citation-Based Scholarly Influence in Academic Neurosurgery

BACKGROUND AND OBJECTIVES: Evaluating citation-based scholarly influence among academic faculty is foundational to academic medicine, as retention, promotion, and tenure to govern career advancement at every level. The h-index has been the standard metric across fields, including...