Baoding People's Hospital

Identification of Two Novel HIV-1 Unique Recombinant Forms Involving CRF07_BC and CRF08_BC Among ART-Failing Patients in Hebei, China

The continuous HIV-1 recombination forms circulating in China poses a persistent challenge to epidemic control. And this study identifies two novel unique recombinant forms (URFs), BDNY017 and BDK025, from antiretroviral therapy (ART)-failing patients in Hebei Province. Near full...

Predicting hemorrhagic transformation in acute ischemic stroke using a machine learning model based on clinical and HR-MRI features

Early prediction of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) is critical for clinical decision-making. We aimed to develop and externally validate a highly interpretable machine learning model integrating high-resolution magnetic resonance imaging (HR-MRI) a...

Etiological characteristics and genotypes of Mycoplasma pneumoniae infection in children in Baoding from 2022 to 2024

ABSTRACT To investigate the epidemiology associated with genetic types and macrolide resistance of Mycoplasma pneumoniae (MP) in children during and post-COVID-19 in Baoding. A retrospective analysis was conducted on 13,534 children and adolescents (≤18 years old) with community-...

Septic arthritis of the hip caused by Streptococcus pyogenes bloodstream infection in a previously healthy adult: a case report

Pyogenic arthritis of the hip joint is a rare but serious complication of invasive Streptococcus pyogenes (group A Streptococcus [GAS]) infection that may rapidly lead to joint destruction and is often difficult to diagnose early. This report describes the case of a previously he...

Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Background Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. Methods We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical...

Defining a minimal clinically important difference for the Vanderbilt ADHD Parent Rating Scale in children with Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition in children and adolescents that poses substantial challenges to health, functioning, and well-being. This study aimed to estimate the minimal clinically important difference (MCID) for th...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...

Esketamine induces ferroptosis and suppresses immune evasion in lung adenocarcinoma cells via the hsa_circ_0022392/miR-548b-3p/MAP7 axis

Abstract Background Although Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used for anesthesia and analgesia and has shown anticancer activity, its effects on lung adenocarcinoma remain unclear. Circular RNAs have been implicated in the development and...